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Keywords: EGFR
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Journal Articles
Journal: Development
Development (2022) 149 (21): dev201094.
Published: 31 October 2022
... interrupts vulval induction and is associated with a reprogramming-like event that preserves the multipotency of vulval precursor cells (VPCs), allowing vulval development to reinitiate if conditions improve. Vulval induction requires the LIN-3/EGF-like signal from the gonad, which activates EGFR-Ras-ERK...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2018) 145 (23): dev168716.
Published: 5 December 2018
... investigated the relationship between two signals, Wnt and EGFR, that are necessary for self-renewal of the epithelial follicle stem cells (FSCs) in the Drosophila ovary, but must be downregulated in cells that have exited the niche to allow for differentiation. We found that Wingless produced by inner...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (22): 4159–4172.
Published: 15 November 2017
... find that loss of Graf impairs GEEC endocytosis, enhances EGFR signaling and induces a plasmatocyte overproliferation phenotype that requires the EGFR signaling cascade. Mechanistically, Graf-dependent GEEC endocytosis serves as a major route for EGFR internalization at high, but not low, doses...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (14): 2673–2682.
Published: 15 July 2017
... the activity of ubiquitin ligases that contain Cullin 1. Analysis of CSN1b mutant phenotypes revealed a requirement for the COP9 signalosome to prevent ectopic expression of Epidermal growth factor receptor (EGFR) target genes. It does so by protecting Capicua, a transcriptional repressor of EGFR target genes...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2015) 142 (8): 1492–1501.
Published: 15 April 2015
... role as a positive effector of the EGF receptor (EGFR), we show that readouts of the EGFR pathway are upregulated in vav mutant larval eye disc and pupal retina, indicating that Vav antagonises EGFR signalling during eye development . Accordingly, decreasing EGFR signalling in vav mutant eyes restores...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (21): 4110–4114.
Published: 1 November 2014
...Christina L. Austin; Sathiya N. Manivannan; Amanda Simcox ErbB receptors, including the epidermal growth factor receptor (Egfr), are activated by EGF ligands to govern cell proliferation, survival, migration and differentiation. The different EGF-induced cell responses in development are regulated...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2011) 138 (14): 2883–2893.
Published: 15 July 2011
... by transient amplification of neural progenitor cells. Loss of Notch function caused all cells of the placode to form as supernumerary IPC NBs, indicating that the placode is initially a fate equivalence group for the IPC NB fate. Loss of Egfr function caused all placodal cells to apoptose, except for the IPC...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (20): 3427–3437.
Published: 15 October 2010
...Tal Rousso; Jeremy Lynch; Shaul Yogev; Siegfried Roth; Eyal D. Schejter; Ben-Zion Shilo Egfr ligand processing in Drosophila involves trafficking of the ligand precursor by the chaperone Star from the endoplasmic reticulum (ER) to a secretory compartment, where the precursor is cleaved...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2010) 137 (13): 2157–2166.
Published: 1 July 2010
... of Notch and Egfr signaling. Second, loss of dacn interferes with cellular starvation responses by inhibiting autophagosome maturation. By contrast, overexpression of dacn causes lethality due to enhanced autophagy. We show that this enhanced autophagy is independent of the Tor pathway. Taken together, our...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (12): 2065–2074.
Published: 15 June 2010
...Cheryl Van Buskirk; Paul W. Sternberg The ancient origin of sleep is evidenced by deeply conserved signaling pathways regulating sleep-like behavior, such as signaling through the Epidermal growth factor receptor (EGFR). In Caenorhabditis elegans , a sleep-like state can be induced at any time...
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2009) 136 (4): 551–561.
Published: 15 February 2009
... a unique model system in which to study GSL roles in signaling in vivo. Here, we use egghead and brainiac mutants to show that GSLs are necessary for full activation of the EGFR pathway during oogenesis in a time-dependent manner. In contrast to results from in vitro studies, we find that GSLs are required...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (3): 473–481.
Published: 1 February 2009
... cell adhesion molecule (NCAM), as a physiologically significant and specific inhibitor of epidermal growth factor receptor (EGFR) signalling in development. We find that loss of fas2 genetically interacts with multiple genetic conditions that perturb EGFR signalling. Fas2 is expressed in dynamic...
Includes: Supplementary data