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Keywords: EGF receptorClose
Development (2015) 142 (8): 1480–1491.
Published: 15 April 2015
..., these findings indicate that Vps4 can promote EGFR activity through an endocytosis-independent mechanism. SUMMARY : The AAA ATPase Vps4 is required for and promotes EGFR activity during Drosophila eye development, acting via an endocytosis-independent mechanism. Vps4 Endocytosis EGF receptor...
Includes: Supplementary data
Development (2008) 135 (24): 3995–4001.
Published: 15 December 2008
... primordium, which extensively proliferates during larval development to give rise to the dorsal thoracic body wall and the adult wing. The developmental decision between wing and body wall is defined by the opposing activities of two secreted signalling molecules, Wingless and the EGF receptor ligand Vein...
Includes: Supplementary data
Development (2004) 131 (8): 1835–1845.
Published: 15 April 2004
... ) * Present address: Center for Neurologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA † Present address: Department of Genomic Sciences, University of Washington,Seattle, WA 98195, USA 30 12 2003 © 2004. 2004 EGF receptor Denticle belt...
Development (2003) 130 (25): 6305–6316.
Published: 22 December 2003
... for correspondence (e-mail: email@example.com and firstname.lastname@example.org ) * These authors contributed equally to this work 9 9 2003 © The Company of Biologists Limited 2003 2003 echinoid Notch EGF receptor Cell adhesion Signaling Bristle patterning The dorsal mesothorax...
Development (2003) 130 (16): 3715–3724.
Published: 15 August 2003
...Emma L. Rawlins; Neil M. White; Andrew P. Jarman EGF receptor signalling plays diverse inductive roles during development. To achieve this, its activity must be carefully regulated in a variety of ways to control the time, pattern, intensity and duration of signalling. We show that the cell surface...
Development (2003) 130 (10): 2051–2059.
Published: 15 May 2003
.... Together,our results suggest a model in which Nrg acts as a heterophilic ligand and activator of Ed, which in turn antagonizes EGFR signaling. † Authors for correspondence (e-mail: email@example.com and firstname.lastname@example.org ) 23 1 2003 © 2003. 2003 EGF receptor Cell adhesion...
Sun-Yun Yu, Soon Ji Yoo, Lihui Yang, Cynthia Zapata, Anu Srinivasan, Bruce A. Hay, Nicholas E. Baker
Development (2002) 129 (13): 3269–3278.
Published: 1 July 2002
... system. In the eye, the EGF receptor, Notch, and intact primary pigment and cone cells have been implicated in survival or death signals. An antibody raised against a peptide from human caspase 3 was used to investigate how extracellular signals controlled spatial patterning of cell death. The antibody...
Development (2001) 128 (15): 3001–3015.
Published: 1 August 2001
... cell migration to form an elaborate branched network essential for oxygen delivery throughout the larva. FGF signaling is required for guided migration of all tracheal branches, whereas the DPP, EGF receptor, and Wingless/WNT signaling pathways each mediate the formation of specific subsets of branches...
Development (2001) 128 (7): 1183–1191.
Published: 1 April 2001
...Lihui Yang; Nicholas E. Baker ABSTRACT The Drosophila EGF receptor is required for differentiation of many cell types during eye development. We have used mosaic analysis with definitive null mutations to analyze the effects of complete absence of EGFR, Ras or Raf proteins during eye development...
Development (2001) 128 (5): 723–732.
Published: 1 March 2001
...Philip R. Elstob; Véronique Brodu; Alex P. Gould ABSTRACT Signaling from the EGF receptor (EGFR) can trigger the differentiation of a wide variety of cell types in many animal species. We have explored the mechanisms that generate this diversity using the Drosophila peripheral nervous system...
Development (2001) 128 (4): 591–601.
Published: 15 February 2001
.... Flies of ed mutant produce extra photoreceptor and cone cells. Conversely, ectopic overexpression of ed in the eye leads to reduction of photoreceptor number. We demonstrate that ED acts by converging on TTK88, the most downstream component known in EGF receptor signaling. Our results not only...
Development (2001) 128 (2): 299–308.
Published: 15 January 2001
... , R. J. and Schüpbach , T. ( 1989 ). Coordinately and differentially mutable activities of torpedo , the Drosophila melanogaster homolog of the vertebrate EGF receptor gene . Genetics 123 , 771 – 787 . 10.1093/genetics/123.4.771 Cubas , P. , de Celis , J. F...
Development (2000) 127 (22): 4993–5005.
Published: 15 November 2000
... cortex Proliferation EGF receptor Stem cell Rat Proliferation and differentiation occur in temporal and spatial patterns in the CNS. These patterns are generated as a result of intrinsic differences in progenitor cells and restricted expression of extrinsic signals (reviewed in Edlund...
Paivi J. Miettinen, Mari-Anne Huotari, Tarja Koivisto, Jarkko Ustinov, Jaan Palgi, Suvi Rasilainen, Eero Lehtonen, Jorma Keski-Oja, Timo Otonkoski
Development (2000) 127 (12): 2617–2627.
Published: 15 June 2000
..., Finland (e-mail: email@example.com ) 23 May 2000 11 April 2000 © 2000 by Company of Biologists 2000 EGF receptor Gene targeting Pancreas Matrixmetalloproteinases Mouse The pancreas develops from foregut endoderm through the fusion of dorsal and ventral...
Development (2000) 127 (7): 1517–1529.
Published: 1 April 2000
... cells are generated, and we identify defects in precursor formation and EGF receptor-dependent inductive processes required for cell-fate specification. The number of neuronal precursors is variable in embryos that lack Spen. The levels of Suppressor of Hairless, a key transcriptional effector of Notch...
Development (2000) 127 (3): 533–542.
Published: 1 February 2000
...@health.missouri.edu ) 10 11 1999 12 01 2000 © 2000 by Company of Biologists 2000 TGFα EGF EGF Receptor Corneal endothelial cell Anterior segment dysgenesis Eye Transgenic mouse In mouse, the development of the anterior segment of the eye begins at about embryonic day 11 (E11...
Development (1999) 126 (14): 3241–3251.
Published: 15 July 1999
... 1999 by Company of Biologists 1999 zfh-1 even-skipped numb Notch spitz EGF receptor Lineage Cell fate Zinc finger Homeodomain Heart Pericardial cell Myocardium Drosophila Mesoderm Cardiogenesis Myogenesis The Drosophila heart is linear and thus very different...
Noreen C. Luetteke, Ting Hu Qiu, Suzanne E. Fssssenton, Kelly L. Troyer, Richard F. Riedel, Aileen Chang, David C. Lee
Development (1999) 126 (12): 2739–2750.
Published: 15 June 1999
.... In contrast to EGF receptor (EGFR) knockout mice, triple null mice lacking half of the EGFR ligand family were healthy and fertile, indicative of overlapping or compensatory functions among EGF family members. Nevertheless, pups born to triple null dams frequently died or were runted, suggesting a mammary...
Development (1998) 125 (17): 3301–3312.
Published: 1 September 1998
... that the segmentation genes specify neuroblast identity along the AP axis. However, little is known as to the control of neuroblast identity along the DV axis. Here, I show that the Drosophila EGF receptor (encoded by the DER gene) promotes the formation, patterning and individual fate specification of early forming...
Development (1998) 125 (2): 191–200.
Published: 15 January 1998
...Amir Sapir; Ronen Schweitzer; Ben-Zion Shilo ABSTRACT Previous work has demonstrated a role for the Drosophila EGF receptor (Torpedo/DER) and its ligand, Gurken, in the determination of anterioposterior and dorsoventral axes of the follicle cells and oocyte. The roles of DER in establishing...