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Keywords: EGF
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Journal Articles
In collection:
Human development
Journal: Development
Development (2023) 150 (11): dev201284.
Published: 1 June 2023
... of the developing lung tip epithelium in vivo . Cell shape dynamics and fate are tightly coordinated during development. We therefore used the organoid system to identify signalling pathways that maintain the columnar shape of human lung tip progenitors. We found that EGF, FGF7 and FGF10 have distinct functions...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (9): 1611–1619.
Published: 1 May 2012
... rhomboid regulates EGF signaling to specify distinct cell types. Recently, we identified a CRM that activates rhomboid expression and thereby EGF secretion from a subset of abdominal sensory organ precursor cells (SOPs) to induce an appropriate number of lipid-processing cells called oenocytes. Here, we...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (23): 5099–5112.
Published: 1 December 2011
... into normal and dysregulated nephrogenesis, as well as into regenerative processes that follow kidney injury. In this study, we found that the mouse CITED1 + progenitor compartment is maintained in response to receptor tyrosine kinase (RTK) ligands that activate both FGF and EGF receptors. This RTK signaling...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2004) 131 (1): 143–151.
Published: 1 January 2004
...Byung Joon Hwang; Paul W. Sternberg During C. elegans vulval development, the anchor cell (AC) in the somatic gonad expresses lin-3 , activating the EGF receptor signaling pathway in vulval precursor cells (VPCs) and thereby inducing and patterning VPCs. Previous studies with lin-3 mutants...
Journal Articles
Journal Articles
Journal: Development
Development (2003) 130 (1): 57–69.
Published: 1 January 2003
... to specificity of this class of mediator protein. * Author for correspondence (e-mail: pws@caltech.edu ) 4 10 2002 © 2003. 2003 EGF RAS LET-23 SOP-1 DPY-22 Mediator Vulva C. elegans Activation of signal transduction pathways by growth factors is frequently used...
Journal Articles
Journal Articles
Journal: Development
Development (2002) 129 (10): 2541–2553.
Published: 15 May 2002
...-expressing cells stimulate Eda expression in whole skin explants (A) as well as in isolated epithelium (B). (C) 3T3 control cells failed to induce Eda . (D-H) None of the other signals tested (activin A, BMP4, EGF, FGF10 and SHH) had stimulatory effects on Eda expression. Scale bar: 200 μm. Fig. 4...
Journal Articles
Journal: Development
Development (2000) 127 (4): 841–850.
Published: 15 February 2000
...Francesca Peri; Siegfried Roth ABSTRACT During Drosophila oogenesis Gurken, associated with the oocyte nucleus, activates the Drosophila EGF receptor in the follicular epithelium. Gurken first specifies posterior follicle cells, which in turn signal back to the oocyte to induce the migration...
Journal Articles
Journal: Development
Development (2000) 127 (3): 533–542.
Published: 1 February 2000
... transgenic mice that express either transforming growth factor α (TGFα) or epidermal growth factor (EGF) in the ocular lens using the mouse αA-crystallin promoter. Expression of either growth factor alters the normal developmental fate of the innermost corneal mesenchymal cells so that these cells often fail...
Journal Articles
Journal Articles
Journal: Development
Development (1999) 126 (11): 2515–2525.
Published: 1 June 1999
...Susanne Kramer; Masataka Okabe; Nir Hacohen; Mark A. Krasnow; Yasushi Hiromi ABSTRACT Extracellular factors such as FGF and EGF control various aspects of morphogenesis, patterning and cellular proliferation in both invertebrates and vertebrates. In most systems, it is primarily the distribution...
Journal Articles
Journal Articles
Journal: Development
Development (1998) 125 (16): 3101–3109.
Published: 15 August 1998
... transcription. In particular, LIN-12::GFP is expressed initially in all six VPCs, but appears to be reduced specifically in P6.p as a consequence of the activation of the Ras pathway by an EGF-like inductive signal from the AC. We propose that downregulation of LIN-12 stability or translation in response...
Journal Articles
Journal: Development
Development (1998) 125 (12): 2337–2347.
Published: 15 June 1998
... sufficient to promote the P12 fate, and the conserved EGF signaling pathway is utilized for P12 fate specification; egl-5 is a downstream target of the lin-3/let-23 pathway in specifying P12 fate; and LIN-44 and LIN-17 act synergistically with lin-3 in the specification of the P12 fate. The Wnt pathway may...
Journal Articles
Journal: Development
Development (1997) 124 (8): 1593–1600.
Published: 15 April 1997
... in this communication indicate that the elevated level of fetal fibroblast migration into 3D-collagen gels and HA synthesis by these cells were not affected by epidermal growth factor (EGF), platelet-derived growth factor (PDGF), acidic fibroblast growth factor (aFGF) or basic fibroblast growth factor (bFGF...
Journal Articles
Journal Articles
Journal: Development
Development (1995) 121 (4): 1005–1014.
Published: 1 April 1995
... tissues, the effect of leukaemia inhibitory factor (LIF) and epidermal growth factor (EGF) on their activity was investigated. Both LIF and EGF, like the proteinases, have been implicated in peri-implantation development. Blastocysts collected on day 4 of pregnancy were cultured 2 days in TCM 199 + 10...