.../ Highlighted Article: Two geminin family proteins function in mammalian multiciliated cell development: GMNC regulates precursor specification and MCIDAS induces multiple basal body formation for multiciliation. Cilia Multiciliated cell GMNC MCIDAS E2F Deuterosome The health of our airways...

... retinal pigment epithelium, photoreceptor loss and early onset of retinal degeneration. Although the retinal defect is associated with increased cyclin D1 and CDK4/6 expression, and RB phosphorylation and E2F-target gene upregulation, it is independent of the EOB phenotype and of JNK. The retinal...

... interacts with a novel BED (BEAF and Dref) finger protein that we have termed Sunspot (Ssp). Ssp transactivates Drosophila E2F-1 ( dE2F-1 ) and PCNA expression, and positively regulates the proliferation of imaginal disc cells and the endoreplication of salivary gland cells. Wg negatively regulates...

... of E2f1 destruction should permit us to directly test whether prevention of E2f1 destruction would affect replication factor gene expression in the embryo. E2F is necessary for the development of worms, flies and mice( DeGregori, 2002 ). Remarkably,however, pRb is not needed for the entirety...

...Woo Chi; Valerie Reinke In Caenorhabditis elegans , EFL-1 (E2F), DPL-1 (DP) and LIN-35(pRb) act coordinately in somatic tissues to inhibit ectopic cell division,probably by repressing the expression of target genes. EFL-1, DPL-1 and LIN-35 are also present in the germline, but do not always act...

.../S transition in the second mitotic wave, rather it delays the completion of S phase and leads to abnormal eye development. These observations suggest that RB/E2F control the rate of S-phase progression instead of G1/S transition in the second mitotic wave. Characterization of the role of RBF...

... for correspondence (e-mail: bedgar@fhcrc.org ) 20 11 2001 © 2002. 2002 Drosophila Tkv Proliferation Growth E2F PI3K Vestigial Development in multicellular organisms requires the coordination of growth and patterning. In the case of Drosophila , the developing adult epidermal...

...Pelin Cayirlioglu; Peter C. Bonnette; M. Ryan Dickson; Robert J. Duronio Drosophila contains two members of the E2F transcription factor family ( E2f and E2f2 ), which controls the expression of genes that regulate the G1-S transition of the cell cycle. Previous genetic analyses have indicated...

...Denise L. Myster; Peter C. Bonnette; Robert J. Duronio ABSTRACT The E2F family of transcription factors contributes to cell cycle control by regulating the transcription of DNA replication factors. Functional ‘E2F’ is a DNA-binding heterodimer composed of E2F and DP proteins. Drosophila contains...

...Wei Du ABSTRACT In mammals, a large number of proteins including E2F transcription factors have been shown to interact with the tumor suppressor gene product pRB, but it is not clear to what extend the function of pRB is mediated by E2F. In addition, E2F was shown to mediate both transcription...