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Keywords: E(Spl)
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Journal Articles
Journal: Development
Development (2012) 139 (7): 1258–1269.
Published: 1 April 2012
... intermediate precursors called GMCs or INPs. We show that E(spl)mγ, E(spl)mβ, E(spl)m8 and Deadpan (Dpn), members of the basic helix-loop-helix-Orange protein family, are expressed in NBs but not in differentiated cells. Double mutation for the E(spl) complex and dpn severely affects the ability of NBs to self...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (18): 3137–3148.
Published: 15 September 2008
... in zebrafish by the E(Spl) factors Her5 and Her11, but the molecular cascades cooperating with Her5/11, and those accounting for their reduced effect in the medial IZ, remain unknown. We demonstrate here that the kinases Gsk3β and cAMP-dependent protein kinase A (PKA) are novel determinants of IZ formation...
Journal Articles
Journal: Development
Development (2006) 133 (21): 4293–4303.
Published: 1 November 2006
... populations in this system, we used an embryonic neural stem cell marker, the E(spl) bHLH transcription factor Her5. We demonstrate that her5 expression is not restricted to embryonic neural progenitors, but also defines in the adult zebrafish brain a new proliferation zone at the junction between the mid...
Journal Articles
Journal: Development
Development (2005) 132 (1): 75–88.
Published: 1 January 2005
... growth and the generation of midbrain-hindbrain neurons. Recently, we implicated the Hairy/E(spl) transcription factor Her5 in the formation of the medial (most basal) part of the IZ (MIZ) in zebrafish; the molecular bases for lateral IZ (LIZ) formation, however, remain unknown. We now demonstrate...
Journal Articles
Journal: Development
Development (2003) 130 (8): 1591–1604.
Published: 15 April 2003
... expression of genes defining MHB identity. We further show that expression of the zebrafish bHLH Hairy/E(spl)-related factor Her5 prefigures and then precisely delineates the IZ throughout embryonic development. Using morpholino knock-down and conditional gain-of-function assays, we demonstrate that Her5...
Journal Articles
Journal: Development
Development (2003) 130 (2): 259–270.
Published: 15 January 2003
... neural fate,whereas the E(spl) repressors suppress it. We show here that E(spl) proteins m7 and mγ are potent inhibitors of neural fate, even in the presence of excess Sc activity and even when their DNA-binding basic domain has been inactivated. Furthermore, these E(spl) proteins can efficiently repress...