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In collection:Reproductive biology
Development (2021) 148 (24): dev200178.
Published: 21 December 2021
... in a DUX-dependent manner. These results suggest that DPPA2 and DPPA4 are essential maternal factors that regulate Dux and ZGA in embryos. By analyzing maternal knockout and maternal-zygotic knockout embryos, we unexpectedly found that DPPA2 and DPPA4 are dispensable for Dux activation, ZGA and pre...
Includes: Supplementary data
Development (2020) 147 (2): dev177725.
Published: 23 January 2020
...Alberto De Iaco; Sonia Verp; Sandra Offner; Delphine Grun; Didier Trono ABSTRACT Some of the earliest transcripts produced in fertilized human and mouse oocytes code for DUX, a double homeodomain protein that promotes embryonic genome activation (EGA). Deleting Dux by genome editing at the one...