... of the Hippo signaling pathway, causes separable effects on growth and differentiation of the Drosophila eye. We present evidence supporting a role for Yki in suppressing eye fate by downregulation of the core retinal determination genes. Other upstream regulators of the Hippo pathway mediate this effect...

...Bomsoo Cho; Janice A. Fischer Ral is a small Ras-like GTPase that regulates membrane trafficking and signaling. Here, we show that in response to planar cell polarity (PCP) signals, Ral modulates asymmetric Notch signaling in the Drosophila eye. Specification of the initially equivalent R3/R4...

... feature of Drosophila eye development is the 90° rotational movement of the multicellular ommatidial precursors within a matrix of stationary cells. We demonstrate that the cell adhesion molecules Echinoid (Ed) and Friend of Echinoid (Fred) act throughout ommatidial rotation to modulate the degree...

..., proliferation and differentiation define the final shape and size of the organ. We have used Drosophila eye to identify the genes required for cell survival and to sustain early growth. Previously, we have shown that ventral is the ground state of the entire early larval eye primordium( Singh and Choi, 2003...

... of lozenge ( lz ), an AML1 homolog expressed during Drosophila eye development. We also present results of genetic interaction experiments with AML1 co-factors that are not consistent with AML1-ETO behaving as a dominant-negative factor. Instead, our data suggest that AML1-ETO acts as a constitutive...

...Janghoo Lim; Kwang-Wook Choi Neurogenesis in Drosophila eye imaginal disc is controlled by interactions of positive and negative regulatory genes. The basic helix-loop-helix (bHLH) transcription factor Atonal (Ato) plays an essential proneural function in the morphogenetic furrow to induce...

...Janghoo Lim; Kwang-Wook Choi Atonal (Ato)/Math (Mammalian atonal homolog) family proneural proteins are key regulators of neurogenesis in both vertebrates and invertebrates. In the Drosophila eye, Ato is essential for the generation of photoreceptor neurons. Ato expression is initiated...

... 2003. 2003 Drosophila eye Morphogenetic furrow Hedgehog Decapentaplegic Notch Delta The adult eye of Drosophila is remarkable for a wave of differentiation that spreads from posterior to anterior across the retina field of the eye imaginal disc. Eight hundred or so ommatidia...

... ). These findings support the notion that gp150 and sca affect a common process, at least in patterning the development of the Drosophila eye. Gp150 may have some additional functions to Sca, as gp150 homozygotes show reduced adult viability in comparison with sca homozygotes, and subtle defects in wing...

... for the inactive N protein in R8 precursor cells. 19 3 2003 © 2003. 2003 Notch Delta Fringe O -fucose Drosophila eye Neurogenesis Lateral inhibition During development, neural cells often arise separated from one another by ectodermal cells. Spacing of neural cells implies...

... to regulate the establishment of tissue polarity in the Drosophila eye. Fly strains used: sev-stbm 14-1 , stbm 153 ,stbm 6cn , FRT42, fmi 192 /CyO (a genetic null allele identified in a screen for novel tissue polarity mutants, T. Wolff,unpublished), fmi frz3 (a gift from D. Gubb), fmi E59 (a gift...

... Drosophila eye Caspase Drice Dronc Notch EGF receptor Hid IAP Apoptosis During development, programmed cell death is regulated by cell-cell signals that either promote or inhibit caspase activation ( Meier et al., 2000a ). The biochemical mechanisms of extracellular regulation...

...Franck Pichaud; Claude Desplan ABSTRACT The Drosophila eye is widely used as a model system to study neuronal differentiation, survival and axon projection. Photoreceptor differentiation starts with the specification of a founder cell R8, which sequentially recruits other photoreceptor neurons...

...Petros Ligoxygakis; Sung-Yun Yu; Christos Delidakis; Nicholas E. Baker ABSTRACT The Notch signalling pathway is involved in many processes where cell fate is decided. Previous work showed that Notch is required at successive steps during R8 specification in the Drosophila eye. Initially, Notch...