1-20 of 1222
Keywords: Drosophila
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Journal Articles
Journal: Development
Development dev.200110.
Published: 10 January 2022
... cooperation between loss of cell architecture and hyperactive signaling pathways. However, our understanding of how these different alterations interact and influence each other remains very incomplete. Using Drosophila paradigms of imaginal wing disc epithelial growth, we have monitored the changes in Notch...
Journal Articles
Journal: Development
Development (2021) 148 (24): dev199866.
Published: 23 December 2021
... of the motor domain acts as a STOP. In contrast, uncoordinated mitochondrial motility was observed in CRISPR/Cas9-GSK3β non-phosphorylatable-KHCS314A Drosophila larval axons, owing to decreased kinesin 1 attachment to microtubules and/or membranes, and reduced ATPase activity. Together, we propose that GSK3β...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (24): dev199991.
Published: 17 December 2021
... the role of the Dorsal protein nuclear gradient along the dorsoventral axis in defining the graded pattern of actomyosin constriction that initiates gastrulation in early Drosophila embryos. Two complementary mechanisms for graded accumulation of mRNAs of crucial zygotic Dorsal target genes were identified...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (24): dev200216.
Published: 17 December 2021
...Carrie M. Spratford; Lauren M. Goins; Fangtao Chi; Juliet R. Girard; Savannah N. Macias; Vivien W. Ho; Utpal Banerjee ABSTRACT Genetic and genomic analysis in Drosophila suggests that hematopoietic progenitors likely transition into terminal fates via intermediate progenitors (IPs) with some...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2021) 148 (24): dev199762.
Published: 15 December 2021
...Samantha A. Russell; Kaitlin M. Laws; Greg J. Bashaw ABSTRACT The Netrin receptor Frazzled/Dcc (Fra in Drosophila ) functions in diverse tissue contexts to regulate cell migration, axon guidance and cell survival. Fra signals in response to Netrin to regulate the cytoskeleton and also acts...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (23): dev199034.
Published: 03 December 2021
... steps including image segmentation, clustering and region boundary smoothing. We illustrate the use of the pipeline using a large dataset obtained during the metamorphosis of the Drosophila pupal notum. We also adapt it to determine regions in which the time evolution of the local deformation rate...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (22): dev199700.
Published: 30 November 2021
...Donald F. Ready; Henry C. Chang ABSTRACT Actomyosin contraction shapes the Drosophila eye's panoramic view. The convex curvature of the retinal epithelium, organized in ∼800 close-packed ommatidia, depends upon a fourfold condensation of the retinal floor mediated by contraction of actin stress...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (22): dev199894.
Published: 29 November 2021
... tubule. Here, we show that Drosophila CUBAM is a tripartite complex composed of Amnionless and two cubilin paralogues, Cubilin and Cubilin2, and that it is required for nephrocyte slit diaphragm (SD) dynamics. Loss of CUBAM-mediated endocytosis induces dramatic morphological changes in nephrocytes...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (22): dev199630.
Published: 22 November 2021
... in the Drosophila ovarian epithelial follicle stem cell (FSC) lineage. First, Ben is part of the JNK signaling pathway, and we found that it, as well as other JNK pathway genes, are essential for differentiation of FSC daughter cells. Our data suggest that JNK signaling promotes differentiation by suppressing...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (19): dev199831.
Published: 14 October 2021
... be influenced by the size, composition or dynamics of contacts between membranes. The initiation of Notch signalling in the Drosophila embryo occurs during cellularization, when lateral cell membranes and adherens junctions are first being deposited, allowing us to investigate the importance of membrane...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (20): dev199731.
Published: 14 October 2021
...) is required for the epithelial re-ordering that occurs during Drosophila pupal wing proximo-distal elongation. We identify the exocyst component Sec15 as a RASSF8 interactor. Loss of RASSF8 elicits cytoplasmic accumulation of Sec15 and Rab11-containing vesicles. These vesicles also contain the nectin-like...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (18): dev199725.
Published: 15 September 2021
... the cellular to subcellular spatial scale in early Drosophila embryogenesis. We show that the MT-SPIM improves the axial-resolution relative to the conventional M-SPIM by a factor of two. We further demonstrate that this axial resolution enhancement improves the automated segmentation of Myosin II distribution...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (16): dev187609.
Published: 13 August 2021
... in nociceptive sensory neurons in Drosophila larvae. Time course analyses reveal that Form3 is cell-autonomously required to promote dendritic arbor complexity. We show that form3 is required for the maintenance of a population of stable dendritic microtubules (MTs), and mutants exhibit defects...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (15): dev192146.
Published: 29 July 2021
... elusive. Here, we have identified CAP and MSP300 as novel actors involved during CB migration. They both exhibit highly similar temporal and spatial expression patterns in Drosophila migrating cardiac cells, and are necessary for the correct number and alignment of CBs, a prerequisite for the coordination...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (11): dev199232.
Published: 14 June 2021
.... Here, using quantitative imaging in Drosophila melanogaster , we investigate how patterned cell shape changes promote tissue bending during early embryogenesis. We find that the transcription factors Twist and Snail combinatorially regulate a multicellular pattern of lateral F-actin density...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (9): dev198796.
Published: 13 May 2021
.... This allows for a developmental or physiological role to be assigned to the wild-type gene. We previously observed that the concurrent loss of Pax6 and Polycomb epigenetic repressors in Drosophila leads the eye to transform into a wing. This fate change is not seen when either factor is disrupted separately...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (8): dev197343.
Published: 26 April 2021
...’ cells, to drive stress resilience during Drosophila renal development and homeostasis . Renal tubules lacking Gadd45 exhibit striking morphogenetic defects (with cell death, inflammatory infiltration and reduced ploidy) and accumulate significant DNA damage in post-embryonic life. In parallel...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (8): dev197087.
Published: 23 April 2021
... the MAP kinases p38 and JNK. The sustained or high activation of these kinases can result in apoptosis, whereas short or low activation can promote regeneration. Using the Ask1-dependent regeneration program, we demonstrate in Drosophila wing that PI3K/Akt signaling is necessary for Ask1 to activate p38...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (7): dev189258.
Published: 15 April 2021
... controls production of the second messenger 3′,5′-cyclic adenosine monophosphate (cAMP). cAMP in turn activates Protein kinase A (PKA), which functions as an inhibitor and (uniquely in Drosophila ) as an activator of Hh signalling. A few mammalian Gαi- and Gαs-coupled G protein-coupled receptors (GPCRs...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (7): dev192344.
Published: 06 April 2021
... tissues over many temporal and spatial scales: BMP gradients as short as 1-2 cell diameters maintain the stem cell niche of the Drosophila germarium over a 24-h cycle, and BMP gradients of several hundred microns establish dorsal-ventral tissue specification in Drosophila , zebrafish and Xenopus embryos...