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Keywords: Dispatched
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Journal Articles
Journal: Development
Development (2017) 144 (19): 3612–3624.
Published: 1 October 2017
... Hedgehog-containing cytonemes and identified a role for the Hedgehog deployment protein Dispatched in cytoneme stabilization. We demonstrate that Hedgehog and Dispatched colocalize in cytonemes, and that cholesterol-modified Hedgehog acts through Dispatched to increase cytoneme occurrence. Live imaging...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (16): 4021–4033.
Published: 15 August 2004
...Hua Tian; Toyoaki Tenzen; Andrew P. McMahon Genetic analyses in Drosophila have demonstrated that a transmembrane protein Dispatched (Disp) is required for the release of lipid-modified Hedgehog (Hh) protein from Hh secreting cells. Analysis of Disp1 null mutant embryos has demonstrated that Disp1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2002) 129 (24): 5753–5765.
Published: 15 December 2002
... sites of synthesis and subsequently moves through the morphogenetic field. The dispatched gene, which encodes a putative multipass membrane protein, was initially identified in Drosophila and is required in Hh-producing cells, where it facilitates the transport of cholesterol-modified Hh. We report...
Journal Articles
Journal: Development
Development (2001) 128 (24): 5119–5127.
Published: 15 December 2001
... pathway. We recovered multiple new alleles of hh and dispatched ( disp ). In addition, we identified a novel component in the hh pathway, which we name central missing ( cmn ). Loss-of-function mutations in cmn cause similar patterning defects to those caused by hh or dispatched ( disp ) mutations...