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Keywords: Dishevelled
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Journal Articles
Journal: Development
Development (2020) 147 (19): dev191981.
Published: 5 October 2020
... proteins. Conditional deletion of Wntless or porcupine, both of which are essential for secretion of Wnts, caused misrotated sensory cells and shortened cochlea – both hallmarks of PCP defects. Wntless-deficient cochleae lacked the polarized PCP components dishevelled 1/2 and frizzled 3/6, while other PCP...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2018) 145 (7): dev143107.
Published: 10 April 2018
...Hyeyoon Lee; Seong-Moon Cheong; Wonhee Han; Youngmu Koo; Saet-Byeol Jo; Gun-Sik Cho; Jae-Seong Yang; Sanguk Kim; Jin-Kwan Han ABSTRACT Dishevelled (Dvl/Dsh) is a key scaffold protein that propagates Wnt signaling essential for embryogenesis and homeostasis. However, whether the antagonism of Wnt...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (19): 3429–3439.
Published: 1 October 2015
... proteins Van Gogh-like (Vangl) and Frizzled (Fzd), as well as the cytoplasmic effectors Prickle (Pk) and Dishevelled (Dvl). Asymmetric localization of these proteins is thought to be central to their function, and understanding the dynamics of these proteins is an important challenge in developmental...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (22): 4354–4365.
Published: 15 November 2014
... blastomere. The ABar and EMS spindles both reorient in response to Wnt signals, but only ABar spindle reorientation is dependent on a new cell contact and on HS and SDN-1. SDN-1 transiently accumulates on the ABar surface as it contacts C, and is required for local concentration of Dishevelled (MIG-5...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (16): 3222–3232.
Published: 15 August 2014
...Linh Thuong Vuong; Bibhash Mukhopadhyay; Kwang-Wook Choi Wingless (Wg)/Wnt signaling is fundamental in metazoan development. Armadillo (Arm)/β-catenin and Dishevelled (Dsh) are key components of Wnt signal transduction. Recent studies suggest that intracellular trafficking of Wnt signaling...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (8): 1693–1702.
Published: 15 April 2013
... one mechanism to control core protein levels in Drosophila , and that without this regulation cellular asymmetry is compromised. Levels of Dishevelled at junctions are regulated by a Cullin-3-Diablo/Kelch ubiquitin ligase complex, the activity of which is most likely controlled by neddylation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (23): 4405–4415.
Published: 1 December 2012
... output; but what might underpin this Notch regulation is not understood. Here, we show that Wnt acts via Dishevelled to inhibit Notch signalling, and that this crosstalk regulates cell-fate specification in vivo during Xenopus development. Mechanistically, Dishevelled binds and directly inhibits CSL...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (14): 2584–2593.
Published: 15 July 2012
..., only cells distal to ligand-producing cells are capable of responding. Here, we show that the asymmetric distribution of planar cell polarity (PCP) proteins correlates with this spatial restriction of Notch activation. Frizzled and Dishevelled are enriched at distal sides of each cell and hence...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (5): 1023–1033.
Published: 1 March 2012
... signals. In the early zebrafish embryo, Wnts recruit the Frizzled receptor and the obligate intracellular signaling component Dishevelled to the plasma membrane, thereby generating local cell contacts important for gastrulation movements ( Witzel et al., 2006 ). To test whether Wnts might alter...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (24): 5441–5450.
Published: 15 December 2011
... experiments implicate Wnt11-like proteins in NC specification in Xenopus embryos. In support of this conclusion, modulation of β-catenin-independent signaling through Dishevelled and Ror2 causes predictable changes in premigratory NC. Morpholino-mediated depletion experiments suggest that Wnt11R, a Wnt...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (15): 3297–3306.
Published: 1 August 2011
... for activation of the endomesoderm GRN. If that cortical region of the egg is removed, addition of Wnt6 rescues endoderm. At a molecular level, the vegetal cortex region contains a localized concentration of Dishevelled (Dsh) protein, a transducer of the canonical Wnt pathway; however, Wnt6 mRNA is not similarly...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (15): 3287–3296.
Published: 1 August 2011
... Motoneuron Planar cell polarity Segmental cell migration Muscle specific kinase MuSK wnt11r Dishevelled unplugged In the vertebrate embryonic trunk, neural crest cells delaminate along the entire length of the dorsal neural tube and then enter distinct migratory routes ( Krull...
Includes: Multimedia, Supplementary data
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2005) 132 (16): 3587–3596.
Published: 15 August 2005
...-box genes and may indicate a general functional mechanism for T-box proteins. † Author for correspondence (e-mail: vlad@imcb.a-star.edu.sg ) * These authors contributed equally to this work 9 6 2005 ©2005. 2005 T-box Cell adhesion Zebrafish Frizzled 7 Dishevelled...
Journal Articles
Journal Articles
Journal: Development
Development (2004) 131 (23): 5909–5921.
Published: 1 December 2004
...Joshua S. Waxman; Anne M. Hocking; Cristi L. Stoick; Randall T. Moon Wnt signaling pathways in vertebrates use the phosphoprotein Dishevelled(Dvl). The cellular responses to Wnt signaling may in part be modulated by Dvl-associated proteins, including Dapper (Dpr). We have cloned and characterized...
Includes: Supplementary data
Journal Articles
Journal Articles