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Keywords: Delta
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Journal Articles
Journal: Development
Development (2022) 149 (4): dev200275.
Published: 18 February 2022
... activity is reduced, quiescence is delayed or altogether bypassed, with some neuroblasts dividing continuously during the embryonic-to-larval transition. During embryogenesis before quiescence, neuroblasts express Notch and the Notch ligand Delta. After division, Delta is partitioned to adjacent GMC...
Includes: Supplementary data
Journal Articles
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Reproductive biology
Journal: Development
Development (2019) 146 (2): dev168963.
Published: 18 January 2019
...Weronika Fic; Celia Faria; Daniel St Johnston ABSTRACT The timing of Drosophila egg chamber development is controlled by a germline Delta signal that activates Notch in the follicle cells to induce them to cease proliferation and differentiate. Here, we report that follicle cells lacking the RNA...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (3): dev159178.
Published: 8 February 2018
..., or via peripheral induction, whereby Delta is produced by a specific cell. When one mechanism is perturbed due to mutations, developmental defects or environmental stress, the remaining mechanism ensures that the niche is formed, perhaps abnormally, but still functional. This guarantees that the germline...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (19): 3602–3611.
Published: 1 October 2017
...Dan O. Mellott; Jordan Thisdelle; Robert D. Burke We have examined regulation of neurogenesis by Delta/Notch signaling in sea urchin embryos. At gastrulation, neural progenitors enter S phase coincident with expression of Sp-SoxC. We used a BAC containing GFP knocked into the Sp-SoxC locus to label...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (8): 1780–1788.
Published: 15 April 2014
...), but the individual cells drift out of synchrony when Delta/Notch signalling fails, causing gross anatomical defects. We and others have suggested that this is because synchrony is maintained by pulses of Notch activation, delivered cyclically by each cell to its neighbours, that serve to adjust or reset the phase...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (7): 1433–1444.
Published: 1 April 2013
...David W. M. Tan; Kim B. Jensen; Matthew W. B. Trotter; John T. Connelly; Simon Broad; Fiona M. Watt Human epidermal stem cells express high levels of β1 integrins, delta-like 1 (DLL1) and the EGFR antagonist LRIG1. However, there is cell-to-cell variation in the relative abundance of DLL1 and LRIG1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (13): 2321–2329.
Published: 1 July 2012
...Pau Formosa-Jordan; Marta Ibañes; Saúl Ares; José María Frade Signaling mediated by the Delta/Notch system controls the process of lateral inhibition, known to regulate neurogenesis in metazoans. Lateral inhibition takes place in equivalence groups formed by cells having equal capacity...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (10): 1718–1723.
Published: 15 May 2012
...-cell-autonomously by upregulating Delta expression and Notch signalling. Reduction in Cdk-dependent multisite phosphorylation of Ngn2 enhances its promoter binding affinity. This leads specifically to an increase in neuronal differentiation without an apparent increase in progenitor maintenance via...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (17): 3823–3833.
Published: 1 September 2011
...Taro Mito; Yohei Shinmyo; Kazuki Kurita; Taro Nakamura; Hideyo Ohuchi; Sumihare Noji Delta/Notch signaling controls a wide spectrum of developmental processes, including body and leg segmentation in arthropods. The various functions of Delta/Notch signaling vary among species. For instance...
Journal Articles
Journal: Development
Development (2009) 136 (6): 975–982.
Published: 15 March 2009
...Amanda T. Pickup; Liang Ming; Howard D. Lipshitz The induction of cone cells in the Drosophila larval eye disc by the determined R1/R6 photoreceptor precursor cells requires integration of the Delta-Notch and EGF receptor signaling pathways with the activity of the Lozenge transcription factor...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (14): 2445–2454.
Published: 15 July 2008
... to recapitulate the demonstrable function of full-length LvNumb. Experiments show that LvNumb requires an active Notch signal to function during NSM specification and that LvNumb functions in the cells responding to Delta and not in the cells presenting the Delta ligand. Furthermore, injection of mRNA encoding...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (6): 1089–1095.
Published: 15 March 2008
... for correspondence (e-mail: jaf@mail.utexas.edu ) 10 1 2008 © 2008. 2008 Notch Delta Epsin Clathrin Auxilin liquid facets Signaling Eye Drosophila Endocytosis Notch signaling is used universally in animals and in nearly every developmental context ( Bray,2006...
Journal Articles
Journal: Development
Development (2007) 134 (19): 3527–3537.
Published: 1 October 2007
... neural plate. Most remarkably, the distinct fates of the eight neural precursors are each determined by a unique combination of inputs from these three signalling pathways. Ciona Ascidian Neural patterning Nodal Delta Notch FGF MEK ERK The central nervous system (CNS) of the Ciona...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (12): 2195–2205.
Published: 15 June 2007
... involvement of Delta-Notch signaling in segmentation. Here, we report that, in the spider Achaearanea tepidariorum , the same signaling pathway exerts a different function in the presumptive caudal region before initiation of segmentation. In the developing spider embryo, the growth zone becomes...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (12): 2369–2378.
Published: 15 June 2007
...-mail: n.daudet@ucl.ac.uk ) * These authors contributed equally to this work 26 3 2007 © 2007. 2007 Notch signalling Serrate Delta Chick embryo Inner ear Otic placode Neuroblasts Hair cell Lateral inhibition Lateral induction The vertebrate inner ear...
Journal Articles
Journal: Development
Development (2007) 134 (6): 1161–1169.
Published: 15 March 2007
... levels of Notch pathway activation, resulting from a germline Delta ligand signal, induce polar cells. Here we show that low Notch activation levels,originating from Delta expressed in the polar follicle cells, are required for stalk formation. The metalloprotease Kuzbanian-like, which cleaves...
Journal Articles
Journal: Development
Development (2007) 134 (3): 591–600.
Published: 1 February 2007
... anterior LG. Pros expression is specifically reduced in fng mutants, and is blocked by antagonism of the N pathway. The N ligand Delta (Dl), which is expressed by a subset of neurons, cooperates with Fng for N signaling in the anterior LG, leading to subtype-specific expression of Pros. Furthermore...
Journal Articles
Journal: Development
Development (2006) 133 (21): 4341–4353.
Published: 1 November 2006
... evidence that during early development of the sea urchin embryo, NLK is expressed in the mesodermal precursors in response to Notch signalling and directs their fate by downregulating TCF. The expression pattern of nlk is strikingly similar to that of Delta and the two genes regulate the expression of each...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (15): 2855–2864.
Published: 1 August 2006
... are required for localised expression of Delta2 , which encodes a divergent form of Delta ligand. Using four distinct reagents to inhibit Delta2/Notch signals, we showed that Delta2 signalling from A-line cells, which activates the Notch/Su(H) pathway in adjacent B-line cells, is required for specification...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (12): 2759–2770.
Published: 15 June 2005
... of a Fellowship of the Japan Society for the Promotion of Science for Junior Scientists. References Ahmad, I., Dooley, C. M. and Polk, D. L. ( 1997 ). Delta-1 is a regulator of neurogenesis in the vertebrate retina. Dev. Biol. 185 , 92 -103. Ahmad, I., Tang, L. and Pham, H. ( 2000...