... species with more complex venation Bicyclus anynana and Pieris canidia . We also test the function of some of these genes in B. anynana . We identify both conserved as well as new domains of decapentaplegic , engrailed , invected , spalt , optix , wingless , armadillo , blistered and rhomboid gene...

...Lichao Luo; Chia Keng Siah; Yu Cai Homeostasis of adult tissues is maintained by a small number of stem cells, which are sustained by their niches. In the Drosophila female germline stem cell (GSC) niche, Decapentaplegic (Dpp) is the primary factor that promotes GSC self-renewal. However...

... cell-like tumor formation. Tumors are caused by derepression of decapentaplegic ( dpp ), which prevents cystoblast differentiation. Interestingly, activation of dpp in escort cells requires the function of the TrxG gene brahma ( brm ), suggesting that loss of PRC1 in escort cells causes Brm-dependent...

...Li-Chin Yao; Sopheap Phin; Jane Cho; Christine Rushlow; Kavita Arora; Rahul Warrior Morphogen gradients play fundamental roles in patterning and cell specification during development by eliciting differential transcriptional responses in target cells. In Drosophila , Decapentaplegic (Dpp), the BMP2...

... proteoglycans HSPG Glycosaminoglycan GAG Bone morphogenetic protein signaling Drosophila embryonic patterning Decapentaplegic Dpp Hedgehog Wingless * Author for correspondence (e-mail: rwarrior@uci.edu ) 6 1 2008 © 2008. 2008 Heparan sulfate proteoglycans (HSPGs...

...Carlos Estella; Richard S. Mann Drosophila leg development requires the cooperation of two secreted signals, Decapentaplegic (Dpp) and Wingless (Wg), to form the proximodistal (PD) axis. Wg and Dpp are also required to pattern the dorsoventral (DV) axis of the leg. Here, we show that Distalless...

...Heuijung Lee; Brian G. Stultz; Deborah A. Hursh The eye/antennal discs of Drosophila form most of the adult head capsule. We are analyzing the role of the BMP family member decapentaplegic ( dpp ) in the process of head formation, as we have identified a class of cis -regulatory dpp mutations( dpp...

... regulators might control organ size and morphology by regulating morphogen production, distribution, and/or transduction. In support of this idea, we and others have previously reported that the distribution of the morphogen Decapentaplegic (Dpp) is different in the developing wing and haltere ( Crickmore...

...Girish S. Ratnaparkhi; Songtao Jia; Albert J. Courey The Rel family transcription factor Dorsal patterns the dorsoventral axis of the Drosophila embryo by activating genes such as twist and snail and repressing genes such as decapentaplegic and zerknüllt . Dorsal represses transcription...

... the differences between these structures,their different size being an obvious one. We show here that Ubx regulates the activity of the Decapentaplegic (Dpp) signaling pathway at different levels, and that this regulation is instrumental in establishing the size difference. Ubx downregulates dpp transcription...

... specification genes by the wingless ( wg ) and decapentaplegic ( dpp ) signaling pathways. Under these conditions, though, terminal eye differentiation proceeds only if tsh expression is transient. References Azpiazu, N. and Morata, G. ( 2000 ). Function and regulation of homothorax in the wing...

...), the Hh signaling target, are enhanced by Sxl. This effect requires the cholesterol but not palmitoyl modification on Hh, and expands the zone of full-length Ci expression. Expansion of Ci activation and its downstream targets, particularly decapentaplegic the Drosophila TGFβ homolog, suggests a mechanism...

...Jonathan D. Zirin; Richard S. Mann Secreted signaling molecules such as Wingless (Wg) and Decapentaplegic(Dpp) organize positional information along the proximodistal (PD) axis of the Drosophila wing imaginal disc. Responding cells activate different downstream targets depending on the combination...

... repressor, which is itself periodically expressed. In order to gain insight into the molecular mechanisms involved in leg sensory organ patterning, we have analyzed a Hedgehog (Hh)- and Decapentaplegic(Dpp)-responsive enhancer of the h gene, which directs expression of h in a narrow stripe in the dorsal leg...

... that gives rise to both a GSC,which remains associated with the CpCs, and a more posterior located cystoblast (CB). The CB upregulates expression of the novel gene, bag of marbles ( bam ), which is necessary for germline differentiation. Decapentaplegic (Dpp), a BMP2/4 homologue, has been postulated to act...

... for GAG synthesis. Furthermore, we find that mutations in sotv and ttv impair Hh, Wg and Decapentaplegic(Dpp) signaling. This contrasts with previous studies that suggested loss of ttv compromises only Hh signaling. Our results may contribute to understanding the biological basis of hereditary multiple...

...Yuki Takei; Yutakahiko Ozawa; Makoto Sato; Akira Watanabe; Tetsuya Tabata The signaling molecules Hedgehog (Hh), Decapentaplegic (Dpp) and Wingless(Wg) function as morphogens and organize wing patterning in Drosophila . In the screen for mutations that alter the morphogen activity, we identified...

...Weimin Fu; Nicholas E. Baker In Drosophila , a wave of differentiation progresses across the retinal field in response to signals from posterior cells. Hedgehog (Hh),Decapentaplegic (Dpp) and Notch (N) signaling all contribute. Clones of cells mutated for receptors and nuclear effectors of one, two...

... expressed in visceral mesoderm parasegment 3 may also be required for normal decapentaplegic expression in this region and normal gastric caecum development. branchless expressed in each trunk visceral mesodermal parasegment serves as a guide for the initial budding of tracheal visceral branches...

...Tor Erik Rusten; Rafael Cantera; Fotis C. Kafatos; Rosa Barrio Transforming growth factor β signaling mediated by Decapentaplegic and Screw is known to be involved in defining the border of the ventral neurogenic region in the fruitfly. A second phase of Decapentaplegic signaling occurs in a broad...