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Keywords: Deadenylation
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Journal Articles
Journal: Development
Development (2022) 149 (12): dev199573.
Published: 16 June 2022
... sequencing, we discovered dynamic changes in poly(A) length through deadenylation and re-polyadenylation. Deadenylation appeared to be mediated by microRNAs (miRNAs), and transcripts with shorter poly(A) tails tend to be sequestered into ribonucleoprotein (RNP) granules for translational repression...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (4): dev168146.
Published: 15 February 2019
... is essential for postnatal liver functional maturation. Liver development Cnot complex Deadenylation mRNA decay Mouse Liver development is regulated by various transcription factors (TFs), such as hepatocyte nuclear factor 4α (HNF4α), GATA and the Foxa family, which were initially identified...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (8): 1424–1433.
Published: 15 April 2016
.... These proteins bind to AU-rich elements in target mRNAs, and promote their deadenylation and decay. We addressed the hypotheses that the absence of ZFP36L3 would result in the accumulation of target transcripts in placenta and/or yolk sac, and that some of these would be important for female reproductive...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (22): 4573–4583.
Published: 15 November 2006
... the deadenylation complex CCR4-NOT, leading to rapid deadenylation and subsequent decay of nanos mRNA. Inhibition of deadenylation causes stabilization of nanos mRNA, ectopic synthesis of Nanos protein and head defects. Therefore, deadenylation is essential for both translational repression and decay of nanos mRNA...