... enlargement, expression analyses of 18 candidate genes were carried out in the termite Hodotermopsis sjostedti . Among those, dachshund ( dac ), which identifies the intermediate domain along the proximodistal appendage axis, showed mandible-specific upregulation prior to the molt into presoldiers, which can...

... regulation of the bantam microRNA (miRNA). The transit from proliferating progenitors to cell cycle quiescent precursors is associated with the progressive loss of Homothorax and gain of Dachshund, a nuclear protein related to the Sno/Ski family of co-repressors. We have identified Dachshund as an inhibitor...

... ( hth )- eyes absent ( eya ) -sine oculis ( so ) -dachshund ( dac ) gene regulatory cassette is involved in this specification. Lamina neurons differentiate from NE progenitors that express hth , eya and so . One of the first events in the differentiation of lamina neurons is the upregulation of dac...

... does not fully explain the regulation of Fmrf . We have found that the Dachshund (Dac) and Eyes Absent (Eya)transcription co-factors participate in this combinatorial code. Previous studies have revealed an intimate link between Dac and Eya during eye development. Here, by analyzing their function...

...Yasuyuki Kida; Yukiko Maeda; Tomoki Shiraishi; Takayuki Suzuki; Toshihiko Ogura Based on recent data, a new view is emerging that vertebrate Dachshund(Dach) proteins are components of Six1/6 transcription factor-dependent signaling cascades. Although Drosophila data strongly suggest a tight link...

...-antennal disc that will become retina. We show that Wingless signalling establishes the border between the retina and adjacent head structures by inhibiting the expression of the eye specification genes eyes absent, sine oculis and dachshund . Ectopic Wingless signalling leads to the repression...

... fate. Here we test which antenna patterning genes are targets of Homothorax, Distal-less and/or Spineless. We report that the antennal expression of dachshund , atonal , spalt , and cut requires Homothorax and/or Distal-less, but not Spineless. We conclude that Distal-less and Homothorax specify...

... types. In the leg, the proximal boundary of bric a brac is established by the medial-patterning gene dachshund , but dachshund alone is insufficient to repress bric a brac , and the expression of the two genes overlaps. In the antenna , the proximal boundary of bric a brac is established by an antenna...

... arise. I further demonstrate that the proximal-distal patterning genes homothorax and dachshund are positively required, while Distal-less is unexpectedly negatively required, to establish the segmental pattern of Notch ligand and fringe expression. Two Serrate enhancers that respond to regulation...

... genetic studies have revealed a developmental system for patterning appendages and identified several genes required for limb development. Among these are: extradenticle ( exd ) , homothorax ( hth ) , dachshund ( dac ), Distal-less ( Dll ) and spalt ( sal ). These limb genes have not been well studied...

..., R. (1935) Book Principles of Insect Morphology . New York: McGraw-Hill). To gain insight into how variations between the antenna and the leg may have arisen, we have compared the epistatic relationships among three major proximodistal patterning genes, Distal-less , dachshund and homothorax...

... rise to the mushroom body and follow its morphogenesis through later embryonic stages. In the late embryo, axons of MB neurons lay down a characteristic pattern of pathways. eyeless ( ey ) and dachshund ( dac ) are expressed in the progenitor cells and neurons of the MB in the embryo and larva...

...Sharyl R. Martini; Gregg Roman; Susanne Meuser; Graeme Mardon; Ronald L. Davis ABSTRACT The dachshund gene of Drosophila encodes a putative transcriptional regulator required for eye and leg development. We show here that dachshund is also required for normal brain development. The mushroom bodies...

... requires Distal-less but not dachshund , while early circular dachshund expression is delimited interiorly by BarH1 and BarH2 . Fig. 3. Defects in tarsal segments 3-5 due to the absence or overexpression of Bar . 1-5, tarsal segments 1-5; pt, pretarsus. (A-F) Late third (A,B,D-F) or early pupal (C...

...Weiping Shen; Graeme Mardon ABSTRACT The dachshund gene encodes a nuclear protein that is required for normal eye development in Drosophila . In the absence of dachshund function, flies develop with severely reduced or no eyes. We show that targeted expression of dachshund is sufficient to direct...