... Quiescence Neuroblast Delta Tribbles Hippo PI3-kinase Dacapo Asymmetric cell division Cell cycle Drosophila National Institutes of Health http://dx.doi.org/10.13039/100000002 National Institute of General Medical Sciences http://dx.doi.org/10.13039/100000057 R01-GM120421...

.... The cyclin-dependent kinase inhibitor Dacapo (Dap), a p21/p27 homolog, acts downstream of the microRNA (miRNA) pathway to regulate the cell cycle in Drosophila melanogaster germline stem cells (GSCs). Tissue-extrinsic signals, including insulin, also regulate cell division of GSCs. We report that intrinsic...

... with cell cycles essentially devoid of the G1-phase. This feature is due to the expression of Cyclin E that precedes each cell division, and the differential expression of the S-transition negative regulator, Dacapo. Thus, apart from endocycles (G/S), which occurred in two out of five terminal cells, two...

.../CDK complex, Dacapo. Notch activity leads to downregulation of String and Dacapo, and activation of Fzr. All three genes are independently responsive to Notch. In addition, Cdh Fzr , an essential gene for endocycles, is sufficient to stop mitotic cycle and promote precocious endocycles when expressed...

...@mail.utexas.edu ) * These authors contributed equally to this work 20 10 2003 © 2004. 2004 Myc dmyc Proto-oncogene Nurse cells Follicle Egg chamber Gene amplification Dacapo Cyclin E Polyploidization Endoreduplication The ability of Myc to participate in these diverse...

... )suggesting that the last division generating two EPCs did not occur. This division apparently is symmetrical. A similar phenotype is observed in 70%twi> fzr embryos ( n =150, data not shown). Because it is thought that Dacapo causes arrest of the last division( Lane et al., 1996 ), and that CycA and Rca1...

... and maintain these two independent cell cycles is unknown. We demonstrate a role for the p21 CIP /p27 Kip1 /p57 Kip2 -like cyclin-dependent kinase inhibitor (cki) dacapo in the maintenance of the meiotic cycle in Drosophila oocytes. Our data indicate that it is through the differential regulation of the cki...

...Claas A. Meyer; Ina Kramer; Rainer Dittrich; Sandra Marzodko; Jan Emmerich; Christian F. Lehner dacapo encodes a CIP/KIP-type inhibitor of Cyclin E/Cdk2 complexes in Drosophila melanogaster . In the embryonic epidermis, dacapo expression starts during G2 of the final division cycle and is required...