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Keywords: DYRK1A
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Journal Articles

Craniofacial dysmorphology in Down syndrome is caused by increased dosage of Dyrk1a and at least three other genes

Yushi Redhead, Dorota Gibbins, Eva Lana-Elola, Sheona Watson-Scales, Lisa Dobson, Matthias Krause, Karen J. Liu, Elizabeth M. C. Fisher, Jeremy B. A. Green, Victor L. J. Tybulewicz
Journal: Development
Development (2023) 150 (8): dev201077.
DOI: https://doi.org/10.1242/dev.201077
Published: 26 April 2023
... and an associated mouse genetic mapping panel, we demonstrate that four Hsa21-orthologous regions of mouse chromosome 16 contain dosage-sensitive genes that cause the DS craniofacial phenotype, and identify one of these causative genes as Dyrk1a . We show that the earliest and most severe defects in Dp1Tyb skulls...
View article titled, Craniofacial dysmorphology in Down syndrome is caused by increased dosage of <span class="search-highlight">Dyrk1a</span> and at least three other genes
Click here to open pdf in another window PDF for Craniofacial dysmorphology in Down syndrome is caused by increased dosage of <span class="search-highlight">Dyrk1a</span> and at least three other genes
Includes: Supplementary data
Journal Articles

The neurodevelopmental disorder risk gene DYRK1A is required for ciliogenesis and control of brain size in Xenopus embryos

Helen Rankin Willsey, Yuxiao Xu, Amanda Everitt, Jeanselle Dea, Cameron R. T. Exner, A. Jeremy Willsey, Matthew W. State, Richard M. Harland
Journal: Development
Development (2020) 147 (21): dev189290.
DOI: https://doi.org/10.1242/dev.189290
Published: 22 June 2020
...Helen Rankin Willsey; Yuxiao Xu; Amanda Everitt; Jeanselle Dea; Cameron R. T. Exner; A. Jeremy Willsey; Matthew W. State; Richard M. Harland; Sally Dunwoodie; John Wallingford ABSTRACT DYRK1A [dual specificity tyrosine-(Y)-phosphorylation-regulated kinase 1 A] is a high-confidence autism risk gene...
View article titled, The neurodevelopmental disorder risk gene <span class="search-highlight">DYRK1A</span> is required for ciliogenesis and control of brain size in Xenopus embryos
Click here to open pdf in another window PDF for The neurodevelopmental disorder risk gene <span class="search-highlight">DYRK1A</span> is required for ciliogenesis and control of brain size in Xenopus embryos
Includes: Supplementary data
Journal Articles

Minibrain drives the Dacapo-dependent cell cycle exit of neurons in the Drosophila brain by promoting asense and prospero expression

In collection:
Neural development
Mirja N. Shaikh, Francisco Gutierrez-Aviño, Jordi Colonques, Julian Ceron, Barbara Hämmerle, Francisco J. Tejedor
Journal: Development
Development (2016) 143 (17): 3195–3205.
DOI: https://doi.org/10.1242/dev.134338
Published: 1 September 2016
... show that minibrain ( mnb ), the Drosophila ortholog of the Down syndrome candidate gene DYRK1A , is transiently expressed in newborn neuronal precursors known as ganglion cells (GCs). Mnb promotes the cell cycle exit of GCs through a dual mechanism that regulates the expression of the cyclin-dependent...
View article titled, Minibrain drives the Dacapo-dependent cell cycle exit of neurons in the Drosophila brain by promoting asense and prospero expression
Click here to open pdf in another window PDF for Minibrain drives the Dacapo-dependent cell cycle exit of neurons in the Drosophila brain by promoting asense and prospero expression
Includes: Supplementary data