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Keywords: DNA replication
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Journal Articles
Journal: Development
Development (2016) 143 (17): 3119–3127.
Published: 1 September 2016
..., CYB-3 drives the early events (DNA replication and NEB), CYB-1 controls chromosome attachment to the metaphase plate, and CYB-3 then promotes anaphase. Fig. 2. Inactivation of cyb-3 delays interphase progression in a replication checkpoint-independent manner. (A) Time-lapse DIC images of a single...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (3): 510–521.
Published: 1 February 2015
... zebrafish have global DNA hypomethylation and display embryonic defects, including a small liver, and they die as larvae. We make the surprising finding that, despite their reduced organ size, uhrf1 mutants express high levels of genes controlling S-phase and have many more cells undergoing DNA replication...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (14): 2892–2903.
Published: 15 July 2013
... financial interests. 12 5 2013 © 2013. Published by The Company of Biologists Ltd 2013 Primordial germ cells PGCs DNA demethylation DNA replication Epigenetic reprogramming In mammalian development, the fertilised oocyte generates diverse cell types that possess...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (20): 3880–3890.
Published: 15 October 2012
...Kristopher H. McConnell; Michael Dixon; Brian R. Calvi DNA replication origin activity changes during development. Chromatin modifications are known to influence the genomic location of origins and the time during S phase that they initiate replication in different cells. However, how chromatin...
Journal Articles
Journal: Development
Development (2012) 139 (1): 63–74.
Published: 1 January 2012
... progression. mRNA encoding geminin-RFP (12 ng) was injected into stage 1 embryos, into a single cell of two-cell (stage 2) embryos and into one cell of four-cell (stage 3) embryos ( Fig. 4 ). Recombinant geminin-RFP is able to decrease the amount of DNA replicated in Xenopus egg extracts ( supplementary...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (22): 3857–3866.
Published: 15 November 2010
... progression during C. elegans development, both in the germ line and in the early embryo. Our results indicate that LRR-1 acts as a nuclear substrate-recognition subunit of a Cullin 2-RING E3 ligase complex (CRL2 LRR-1 ), which ensures DNA replication integrity. LRR-1 contains a typical BC/Cul-2 box and binds...
Journal Articles
Journal: Development
Development (2005) 132 (3): 579–589.
Published: 1 February 2005
... GFP-PCNA XCL100 ERK Sea urchin DNA replication References Abrieu, A., Doree, M. and Fisher, D. ( 2001 ). The interplay between cyclin-B-Cdc2 kinase (MPF) and MAP kinase during maturation of oocytes. J. Cell Sci. 114 , 257 -267. Alessi, D. R., Smythe, C. and and Keyse, S. M...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (19): 4807–4818.
Published: 1 October 2004
... these developmentally specific types of DNA replication. Moreover, the ability of the CDK site mutant to rapidly inhibit BrdU incorporation suggests that Dup is required for fork elongation during amplification. In the context of findings from human and other cells, our results indicate that stringent regulation of Dup...
Journal Articles
Journal: Development
Development (2004) 131 (9): 2089–2099.
Published: 1 May 2004
... for the activity of nearby DNA replication origin(s). Ori-β is the major origin in the locus, and is a sequence-specific element that is sufficient for high-level amplification in combination with ACE3. Sequence requirements for amplification were examined using a transgenic construct that was buffered from...
Journal Articles
Journal: Development
Development (2003) 130 (13): 2997–3005.
Published: 1 July 2003
... ). Embryos lacking Gnu protein undergo DNA replication and centrosome proliferation without chromosome condensation or mitotic segregation. We have identified the gnu gene encoding a novel phosphoprotein dephosphorylated by Protein phosphatase 1 at egg activation. Gnu is normally expressed in the nurse cells...
Journal Articles
Journal: Development
Development (1985) 89 (Supplement): 257–270.
Published: 1 November 1985
... developmental events, particularly those associated with transcriptional activities, require DNA replication prior to their occurrence, suggesting an intimate relationship between DNA replication cycles and their onset. On the other hand, there are many other developmental events where timing is not controlled...
Journal Articles
Journal: Development
Development (1985) 89 (Supplement): 285–296.
Published: 1 November 1985
...R. A. Laskey Eggs of Xenopus laevis contain exceptionally large amounts of materials involved in chromosome replication. This maternal stockpile allows an embryo to produce about 80 000 cells in less than 24 h. The adaptations which achieve this involve the mechanisms of both DNA replication...
Journal Articles
Journal: Development
Development (1985) 89 (Supplement): 271–284.
Published: 1 November 1985
... population (Prescott 1976, Smith & Martin, 1973). Once a cell is committed to enter S phase, the duration of S, G2 and M is relatively constant. Adult cells are characterized by a relatively long Gi which may reflect an Key words: oocyte maturation, cell cycle, DNA replication, mitosis, maturation promoting...
Journal Articles
Journal: Development
Development (1985) 89 (1): 133–148.
Published: 1 October 1985
... from G 1 of the 4-cell stage resulted in inhibition of DNA replication and prevention of division from 4 to 8 cells, but was without effect on the timing or incidence of cell flattening, surface polarization and cytoplasmic polarization. The continuous presence of aphidicolin from G 1 of the 2-cell...