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Keywords: DNA methylation
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Journal Articles
Journal: Development
Development (2023) 150 (13): dev201606.
Published: 30 June 2023
...Rhizlane El Omri-Charai; Isabelle Gilbert; Julien Prunier; Rebecka Desmarais; Mariana Gabriela Ghinet; Claude Robert; Guylain Boissonneault; Géraldine Delbes ABSTRACT In mammals, a near complete resetting of DNA methylation (DNAme) is observed during germline establishment. This wave of epigenetic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (24): dev182683.
Published: 15 December 2022
...Alex Wei; Hao Wu ABSTRACT DNA methylation is a highly conserved epigenetic modification that plays essential roles in mammalian gene regulation, genome stability and development. Despite being primarily considered a stable and heritable epigenetic silencing mechanism at heterochromatic...
Journal Articles
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Journal: Development
Development (2020) 147 (6): dev185629.
Published: 17 March 2020
... with significant epigenetic changes. Notably, we identify a cohort of differentially methylated regions (DMRs), most of which gain DNA methylation between the early and late stages of decidualisation. These DMRs are enriched at progesterone-responsive gene loci that are essential for reproductive function...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2019) 146 (12): dev170217.
Published: 27 June 2019
... measurements of chromatin modifications, describing how these methods can be used to connect chromatin and gene expression, classify cell types, and study development and disease. DNA methylation Chromatin regulation Gene regulation Histone modifications Single cell detection Most cells...
Journal Articles
Journal: Development
Development (2019) 146 (7): dev171017.
Published: 11 April 2019
... miRNA-gene regulatory circuit, conserved in cancer, that controls the timing of neural crest epithelial-to-mesenchymal transition. EMT Neural crest miR-203 Snail2 DNA methylation Phf12 Migration The neural crest is a transient embryonic cell population that arises...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (6): dev170902.
Published: 15 March 2019
... of thousands, and their function with regard to altering DNA methylation and histone marks is dose-dependent and thus variable. As such, the phenotypic output shows a ‘noisy’ pattern: the magnitude of the phenotype may depend on the strength of signal input, such as the frequency, intensity and timing...
Journal Articles
Journal: Development
Development (2018) 145 (7): dev160622.
Published: 29 March 2018
...Jennifer M. SanMiguel; Lara K. Abramowitz; Marisa S. Bartolomei ABSTRACT Imprinted genes are expressed from one parental allele and regulated by differential DNA methylation at imprinting control regions (ICRs). ICRs are reprogrammed in the germline through erasure and re-establishment of DNA...
Includes: Supplementary data
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In collection:
Plant development
Journal: Development
Development (2016) 143 (23): 4452–4461.
Published: 1 December 2016
...Yuhua Wang; Xueyi Xue; Jian-Kang Zhu; Juan Dong DNA methylation and histone modifications interact to modulate gene expression in biological organisms. The histone demethylase IBM1 suppresses DNA methylation and gene silencing, primarily by targeting genic regions in the Arabidopsis genome...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (22): 4161–4166.
Published: 15 November 2016
... that this ‘imprinting reporter mouse’ can be used to detect tissue-specific Dlk1 expression patterns in developing embryos. We also apply this system to pluripotent cell culture and demonstrate that it faithfully indicates DNA methylation changes induced upon cellular reprogramming. Finally, the reporter system reveals...
Includes: Supplementary data
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Journal Articles
Journal: Development
Development (2015) 142 (12): 2163–2172.
Published: 15 June 2015
...Ellen N. Elliott; Karyn L. Sheaffer; Jonathan Schug; Thaddeus S. Stappenbeck; Klaus H. Kaestner The DNA methyltransferase Dnmt1 maintains DNA methylation patterns and genomic stability in several in vitro cell systems. Ablation of Dnmt1 in mouse embryos causes death at the post-gastrulation stage...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (3): 510–521.
Published: 1 February 2015
...Vinitha Jacob; Yelena Chernyavskaya; Xintong Chen; Poh Seng Tan; Brandon Kent; Yujin Hoshida; Kirsten C. Sadler UHRF1 (ubiquitin-like, containing PHD and RING finger domains, 1) recruits DNMT1 to hemimethylated DNA during replication and is essential for maintaining DNA methylation. uhrf1 mutant...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2014) 141 (13): 2568–2580.
Published: 1 July 2014
...Ryohei Nakamura; Tatsuya Tsukahara; Wei Qu; Kazuki Ichikawa; Takayoshi Otsuka; Katsumi Ogoshi; Taro L. Saito; Kouji Matsushima; Sumio Sugano; Shinichi Hashimoto; Yutaka Suzuki; Shinichi Morishita; Hiroyuki Takeda DNA methylation is a fundamental epigenetic modification in vertebrate genomes...
Includes: Supplementary data