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Development (2008) 135 (9): 1635–1645.
Published: 1 May 2008
... it is the major mechanism. However, a general problem with this mechanism is the possibility that different inducers are required for each cell type that arises independently of positional information. Consistent with this idea, in Dictyostelium the signalling molecule DIF acts as a position-independent signal...
Development (2004) 131 (18): 4555–4565.
Published: 15 September 2004
...-inducing action of DIF-1 but largely refractory to the repressive effect exerted by extracellular cAMP. During normal development, apically situated prestalk cells express the ecmB gene just as they commit themselves to stalk cell differentiation. In the Ax2/gskA– mutant, ecmB is expressed throughout...
Development (2003) 130 (4): 797–804.
Published: 15 February 2003
...Masashi Fukuzawa; Tomoaki Abe; Jeffrey G. Williams Dd-STATc becomes tyrosine phosphorylated, dimerises and accumulates in the nuclei of Dictyostelium cells exposed to DIF, the chlorinated hexaphenone that directs prestalk cell differentiation. By performing cytoplasmic photobleaching of living...
Jeff Williams, Neil Hopper, Anne Early, David Traynor, Adrian Harwood, Tomoaki Abe, Marie Noelle Simon, Michel Véron
Development (1993) 119 (Supplement): 1–7.
Published: 1 December 1993
... differentiation is induced by DIF, a chlorinated hexaphenone, and a repression mechanism prevents DIF acting to induce premature stalk cell differentiation during slug migration. At culmination intracellular cAMP levels rise, the cAMP dependent protein kinase (PKA) is activated and the block to stalk cell...
Development (1989) 107 (Supplement): 91–97.
Published: 1 April 1989
...J. G. Williams; K. A. Jermyn; K. T. Duffy The pDd63 and pDd56 genes encode extracellular matrix proteins which, respectively, surround the migratory slug and mature stalk cells. Both genes are dependent for their expression upon, and rapidly induced by, DIF, the stalk cell inducer. Using...