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Keywords: DICER1
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Journal Articles
Journal: Development
Development (2015) 142 (17): 2981–2995.
Published: 1 September 2015
... phenotype in vitro . Analysis of human lung tissues revealed decreased YY1 expression in children with pleuropulmonary blastoma (PPB), a rare pediatric lung tumor arising during fetal development and associated with DICER1 mutations. No evidence for a potential genetic interplay between murine Dicer and Yy1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (14): 2487–2498.
Published: 15 July 2015
... in a variety of ocular tissues, and a few were implicated to play role in RPE based on studies in cell lines. Here, through RPE-specific conditional mutagenesis of Dicer1 or D gcr 8 in mice, the importance of miRNAs for RPE differentiation was uncovered. miRNAs were found to be dispensable for maintaining RPE...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (1): 127–138.
Published: 1 January 2011
... of these various cell types requires a coordinated sequence of patterning, specification and differentiation events. We investigated the roles of microRNAs (miRNAs) in the development of optic cup (OC)-derived structures. We inactivated Dicer1, a key mediator of miRNA biosynthesis, within the OC in overlapping yet...
Includes: Supplementary data