.... Here, we defined the roles of cyclin-dependent kinase inhibitor (CKI) p57 KIP2 , an important regulator of G1 phase, using deletion mutant mice. Mutant mice displayed macroencephaly associated with cortical hyperplasia during late embryogenesis and postnatal development. Embryonically, proliferation...

...@mail.nih.gov ) 8 1 2003 © 2003. 2003 Zebrafish Midbrain-hindbrain boundary MHB Neurogenesis Her5 bHLH E(spl) Hairy Proliferation Cyclin-dependent kinase inhibitor p27 A conspicuous feature of the vertebrate embryonic CNS is the absence of a homogeneous gradient...

... have demonstrated the importance of cyclin-dependent kinase inhibitor (CDKI) proteins as negative regulators of proliferation in the developing CNS ( Cunningham and Roussel,2001 ). Two families of mammalian CDKI proteins are known: the Ink4 family, comprising p15 Ink4a , p16 Ink4b ,p18 Ink4c and p19...

...-proliferative state throughout the adult life of the animal. Here we report that the correct timing of cell cycle withdrawal in the developing organ of Corti requires p27 Kip1 , a cyclin-dependent kinase inhibitor that functions as an inhibitor of cell cycle progression. p27 Kip1 expression is induced...