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Keywords: Cyclin-dependent kinase inhibitor
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Journal Articles
Journal: Development
Development (2012) 139 (3): 475–487.
Published: 1 February 2012
.... Here, we defined the roles of cyclin-dependent kinase inhibitor (CKI) p57 KIP2 , an important regulator of G1 phase, using deletion mutant mice. Mutant mice displayed macroencephaly associated with cortical hyperplasia during late embryogenesis and postnatal development. Embryonically, proliferation...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2003) 130 (3): 539–552.
Published: 1 February 2003
... have demonstrated the importance of cyclin-dependent kinase inhibitor (CDKI) proteins as negative regulators of proliferation in the developing CNS ( Cunningham and Roussel,2001 ). Two families of mammalian CDKI proteins are known: the Ink4 family, comprising p15 Ink4a , p16 Ink4b ,p18 Ink4c and p19...
Journal Articles
Journal: Development
Development (1999) 126 (8): 1581–1590.
Published: 15 April 1999
...-proliferative state throughout the adult life of the animal. Here we report that the correct timing of cell cycle withdrawal in the developing organ of Corti requires p27 Kip1 , a cyclin-dependent kinase inhibitor that functions as an inhibitor of cell cycle progression. p27 Kip1 expression is induced...