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Keywords: Cyclin E
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Journal Articles
Journal: Development
Development (2013) 140 (3): 530–540.
Published: 1 February 2013
... to minimize susceptibility to differentiation factors. Drosophila female germline stem cells (GSCs) have short G1 and long G2 phases, and diet-dependent systemic factors often modulate G2. We previously observed that Cyclin E (CycE), a known G1/S regulator, is atypically expressed in GSCs during G2/M; however...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (11): 2223–2234.
Published: 1 June 2011
... and meiotic cell fate. Mitotic cell cycle progression occurs rapidly, continuously, with little or no time spent in G1, and with cyclin E (CYE-1) levels and activity high throughout the cell cycle. In addition to driving mitotic cell cycle progression, CYE-1 and CDK-2 also play an important role...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (2): 251–260.
Published: 15 January 2011
... multiple proteins for degradation, including the G1-S regulator Cyclin E and the oncoprotein dMyc/c-Myc. Despite prominent roles in growth control, little is known about the signals that regulate Ago/Fbw7 abundance in developing tissues. Here we use the Drosophila eye as a model to identify developmental...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (8): 1451–1461.
Published: 15 April 2008
... by the APC/C-dependent oscillation of the pre-replication complex component Orc1. Taken together, our data suggest a model in which the cyclic activity of APC/C Fzr/Cdh1 during the Drosophila endocycle is driven by the periodic inhibition of Fzr/Cdh1 by Cyclin E/Cdk2. We propose that, as is observed...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (19): 4807–4818.
Published: 1 October 2004
... phase. We have investigated the developmental regulation of Double-parked (Dup) protein, the Drosophila ortholog of Cdt1, a conserved and essential pre-RC component found in human and other organisms. We find that phosphorylation and degradation of Dup protein at G 1 /S requires cyclin E/CDK2. The N...
Journal Articles
Journal: Development
Development (2004) 131 (10): 2317–2327.
Published: 15 May 2004
... the opposite effect. BrdU incorporation and Cyclin E protein levels continue to oscillate in dMyc-overexpressing cells, indicating that the normal cell cycle control mechanisms are not disrupted. dMyc driven growth and endoreplication are strongly attenuated when the endocycle is blocked with Cyclin E...
Journal Articles
Journal: Development
Development (2004) 131 (5): 1123–1134.
Published: 1 March 2004
... to upregulation of Cyclin E in late GMC and its unequal distribution between two daughter cells. GMCs in an embryo overexpressing Cyclin E , or in an embryo mutant for archipelago , also undergo self-renewing asymmetric divisions. Although the GMC self-renewal is independent of inscuteable and numb , the fate...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (4): 775–786.
Published: 15 February 2004
... for correspondence (e-mail: d.stein@mail.utexas.edu ) * These authors contributed equally to this work 20 10 2003 © 2004. 2004 Myc dmyc Proto-oncogene Nurse cells Follicle Egg chamber Gene amplification Dacapo Cyclin E Polyploidization Endoreduplication Since...
Journal Articles
Journal: Development
Development (2003) 130 (25): 6339–6349.
Published: 22 December 2003
..., Cyclin A persists longer than in wild type. In addition, Cyclin E expression is not downregulated after the fourth mitosis and accumulates in a polyubiquitinated form. Mutations in genes coding for components of the SCF pathway such as cul1, UbcD2 and effete enhance the extra division phenotype of encore...
Journal Articles
Journal: Development
Development (2003) 130 (7): 1235–1242.
Published: 1 April 2003
... Dacapo that two modes of cell-cycle regulation are independently maintained within the common cytoplasm of ovarian cysts. 20 12 2002 © 2003. 2003 * Author for correspondence (e-mail: mlilly@helix.nih.gov ) Oogenesis Meiosis dacapo p27 Drosophila Cyclin E Oocyte...
Journal Articles
Journal: Development
Development (2002) 129 (6): 1345–1356.
Published: 15 March 2002
..., the Drosophila RB family homolog, in cell cycle progression in the second mitotic wave. RBF-280, a mutant form of RBF that has four putative cdk phosphorylation sites mutated, can no longer be regulated by Cyclin D or Cyclin E. Expression of RBF-280 in the developing eye revealed that RBF-280 does not inhibit G1...