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Keywords: Crumbs
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Journal Articles
Journal: Development
Development (2019) 146 (15): dev175497.
Published: 12 August 2019
...Francisca Nunes de Almeida; Rhian F. Walther; Mary T. Pressé; Evi Vlassaks; Franck Pichaud ABSTRACT Cdc42 regulates epithelial morphogenesis together with the Par complex (Baz/Par3-Par6-aPKC), Crumbs (Crb/CRB3) and Stardust (Sdt/PALS1). However, how these proteins work together and interact during...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (9): dev171207.
Published: 7 May 2019
... lacking Crb2a, a component of the Crumbs polarity complex, display compact wall integrity defects and fail to form trabeculae. Crb2a localization is very dynamic at a time when other cardiomyocyte junctional proteins also relocalize. Before the initiation of cardiomyocyte delamination to form...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (19): 3506–3513.
Published: 1 October 2016
... regulates wing growth by antagonizing the function of the transmembrane protein Crumbs (Crb). Ebi physically binds to the extracellular domain of Crb (Crb ext ), and this interaction is specifically mediated by WD40 repeats 7-8 of Ebi and a laminin G domain of Crb ext . Wing notching resulting from reduced...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (10): 1869–1878.
Published: 15 May 2015
...Kristin M. Sherrard; Richard G. Fehon The transmembrane protein Crumbs (Crb) functions in apical polarity and epithelial integrity. To better understand its role in epithelial morphogenesis, we examined Crb localization and dynamics in the late follicular epithelium of Drosophila . Crb...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (1): 13–21.
Published: 1 January 2013
... . Biochem. Biophys. Res. Commun. 317 , 703 – 707 . Campbell K. , Knust E. , Skaer H. ( 2009 ). Crumbs stabilises epithelial polarity during tissue remodelling . J. Cell Sci. 122 , 2604 – 2612 . Chant J. , Herskowitz I. ( 1991 ). Genetic control of bud site...
Journal Articles
Journal: Development
Development (2012) 139 (24): 4549–4554.
Published: 15 December 2012
...Clothilde Pénalva; Vincent Mirouse Patj is described as a core component of the Crumbs complex. Along with the other components, Crumbs and Stardust, Patj has been proposed as essential for epithelial polarity. However, no proper in vivo genetic analysis of Patj function has been performed in any...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (4): 641–650.
Published: 15 February 2010
...Emily C. N. Richardson; Franck Pichaud Crumbs (Crb) is a conserved apical polarity determinant required for zonula adherens specification and remodelling during Drosophila development. Interestingly, crb function in maintaining apicobasal polarity appears largely dispensable in primary epithelia...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (11): 2007–2016.
Published: 1 June 2007
... and forms ectopic folds rather than closing to make the neural tube. In contrast to zebrafish and Drosophila , in which orthologs of Epb4.1l5 control the apical localization and activity of Crumbs proteins, mouse Crumbs proteins are localized normally to the apical surface of the lulu mutant epiblast...
Journal Articles
Journal: Development
Development (2005) 132 (9): 2035–2045.
Published: 1 May 2005
... of DE-cadherin, the intracellular domain of Crumbs, or by a dominant version of the monomeric GTPase Rho1 prevents localisation of the transmembrane protein IrreC-rst to the border between primary pigment cells and IOCs. As a consequence, the IOCs are not properly sorted and supernumerary cells survive...
Journal Articles
Journal: Development
Development (2005) 132 (5): 977–986.
Published: 1 March 2005
.... Wodarz, A., Hinz, U., Engelbert, M. and Knust, E. ( 1995 ). Expression of crumbs confers apical character on plasma membrane domains of ectodermal epithelia of Drosophila. Cell 82 , 67 -76. Yamanaka, T., Horikoshi, Y., Suzuki, A., Sugiyama, Y., Kitamura,K., Maniwa, R., Nagai, Y., Yamashita...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2003) 130 (18): 4363–4372.
Published: 15 September 2003
...Sang-Chul Nam; Kwang-Wook Choi Apicobasal cell polarity is crucial for morphogenesis of photoreceptor rhabdomeres and adherens junctions (AJs) in the Drosophila eye. Crumbs (Crb) is specifically localized to the apical membrane of photoreceptors, providing a positional cue for the organization...
Journal Articles
Journal: Development
Development (2002) 129 (23): 5437–5447.
Published: 1 December 2002
.... In this process, dome controls the expression of the apical determinant Crumbs. In contrast to the ligand Upd, whose expression is limited to a pair of polar cells at both ends of the egg chamber, dome is expressed in all germline and follicle cells. However, the Dome protein is specifically localized...
Journal Articles
Journal: Development
Development (1993) 119 (Supplement): 261–268.
Published: 1 December 1993
...Elisabeth Knust; Ulrich Tepaß; Andreas Wodarz Loss-or-function imitations in the Drosophila genes crumbs and stardust are embryonic lethal and cause a breakdown of ectodermally derived epithelia during organogenesis, leading to formation of irregular cell clusters and extensive cell death in some...