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Keywords: Cre/loxP
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Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2020) 147 (13): dev190371.
Published: 3 July 2020
... for trophectodermal Tat-Cre/loxP recombination. We used the natural permeability barrier in mouse blastocysts in combination with off-the-shelf Tat-Cre recombinase to achieve editing of conditional alleles in the trophoblast lineage. This direct approach enables gene function analysis during implantation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (13): dev164913.
Published: 27 June 2019
...Congde Chen; Chiyo Shiota; Guy Agostinelli; Daniel Ridley; Yinan Jiang; Jie Ma; Krishna Prasadan; Xiangwei Xiao; George K. Gittes ABSTRACT The Cre/loxP system has been used extensively in mouse models with a limitation of one lineage at a time. Differences in function and other properties among...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (4): 916–925.
Published: 15 February 2013
... line and labeled NC cells by inducing Cre/loxP recombination with tamoxifen at embryonic stages. In juvenile and adult fish, we identified numerous established NC derivatives and, in the cranium, we precisely defined the crest/mesoderm interface of the skull roof. We show the NC origin of the opercular...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (24): 4037–4047.
Published: 15 December 2008
... progenitor cells Retinogenesis Crx Cre/ loxP As in other regions of the CNS, neuronal diversity in the retina originates from a common pseudostratified layer of mitotically active neuroepithelium. The retinal neuroepithelium emerges from the distal tip of the optic vesicles(OVs), established...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (7): 1311–1322.
Published: 1 April 2007
... and endows them with neurogenic properties. Using a Cre/ loxP -based approach, we studied the effect of conditional activation of two Pax6 isoforms, Pax6 and Pax6-5a ,on the corticogenesis of transgenic mice. We found that activation of either Pax6 or Pax6-5a inhibits progenitor proliferation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (7): 1367–1378.
Published: 1 April 2006
... function directly during retinal neurogenesis by selective Cre/ loxP -triggered Notch1 gene inactivation in peripheral retinal progenitor cells (RPCs) prior to the onset of cell differentiation. Consistent with its previously established role, Notch1 inactivation led to dramatic alteration...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2003) 130 (6): 1101–1111.
Published: 15 March 2003
... in the early telencephalon. In particular, Fgf8 is expressed at the anterior end of the telencephalon and is hypothesized to pattern it along the anteroposterior (AP) axis. Using a CRE/ loxP genetic approach to disrupt genes in the telencephalon, we address the role of FGF signaling directly in vivo...
Journal Articles
Journal: Development
Development (2003) 130 (1): 103–109.
Published: 1 January 2003
... of a conditional Jun allele by cre/LoxP-mediated recombination was used to screen for novel functions of Jun and revealed that its absence results in severe malformations of the axial skeleton. More-specific Jun deletion by collagen2a1-cre demonstrated the essential function of Jun in the notochord and sclerotome...
Journal Articles
Journal: Development
Development (2002) 129 (8): 1829–1838.
Published: 15 April 2002
... embryonic death. In the present study, we have specifically inactivated this gene in hepatocytes and bile duct cells using the Cre/loxP system. Mutant animals exhibited severe jaundice caused by abnormalities of the gallbladder and intrahepatic bile ducts (IHBD). The paucity of small IHBD was linked...