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Keywords: Craniofacial
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Journal Articles
Journal Articles
Journal: Development
Development (2024) 151 (2): dev202110.
Published: 24 January 2024
... function in craniofacial development. Mice with BRD4 NCC loss of function died at birth with severe facial hypoplasia, cleft palate, mid-facial clefting and exencephaly. Following migration, BRD4 mutant NCCs initiated RUNX2 expression for differentiation to osteoblast lineages but failed to induce...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2023) 150 (24): dev201786.
Published: 11 December 2023
... of endothelin signaling during craniofacial, cardiovascular, melanocyte and enteric nervous system development and describes the evolutionary conservation of endothelin action and implications to human health. G protein Craniofacial Cardiovascular Enteric Melanocyte Hirschsprung disease...
Journal Articles
Journal: Development
Development (2023) 150 (19): dev202077.
Published: 9 October 2023
...Kuo-Chang Tseng; J. Gage Crump ABSTRACT The evolution of a unique craniofacial complex in vertebrates made possible new ways of breathing, eating, communicating and sensing the environment. The head and face develop through interactions of all three germ layers, the endoderm, ectoderm and mesoderm...
Journal Articles
Journal Articles
Journal: Development
Development (2023) 150 (3): dev201038.
Published: 15 February 2023
... a highly penetrant cleft palate phenotype, shortened limbs compared with wild type and perinatal lethality. Fzd2 D4 craniofacial tissues indicated decreased canonical Wnt signaling. In utero treatment with IIIC3a (a DKK inhibitor) normalized the limb lengths in Fzd2 D4 homozygotes. The in vivo replication...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2021) 148 (9): dev193755.
Published: 7 May 2021
... of order/disorder as well as symmetry/asymmetry, revealing developmental instabilities that are part of normal morphogenesis. Craniofacial Avian embryo Frontonasal Fluctuating asymmetry Mathematical analysis Live cell imaging Organ culture Actomyosin Facial morphogenesis requires...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (18): dev188631.
Published: 12 March 2021
... comparison (morphometrics) traditionally uses manually located landmarks and is limited by landmark number and operator accuracy. Here, we apply a landmark-free method to characterise the craniofacial skeletal phenotype of the Dp1Tyb mouse model of Down syndrome and a population of the Diversity Outbred (DO...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (24): dev194498.
Published: 23 December 2020
... complementary models indicate that disruption of Irf6 and Esrp1/2 in mouse and zebrafish results in orofacial clefts, with an aberrant mesenchymal/epithelial cell population identified in the cleft of the esrp1/2 zebrafish mutant. IRF6 ESRP1 Craniofacial Cleft Development Development...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2020) 147 (21): dev187997.
Published: 17 July 2020
...Karl B. Shpargel; Cassidy L. Mangini; Guojia Xie; Kai Ge; Terry Magnuson; Sally Dunwoodie; John Wallingford ABSTRACT Kabuki syndrome (KS) is a congenital craniofacial disorder resulting from mutations in the KMT2D histone methylase (KS1) or the UTX histone demethylase (KS2). With small cohorts...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (11): dev190488.
Published: 11 June 2020
...Ceilidh Marchant; Peter Anderson; Quenten Schwarz; Sophie Wiszniak ABSTRACT Craniofacial development is a complex morphogenic process that requires highly orchestrated interactions between multiple cell types. Blood vessel-derived angiocrine factors are known to promote proliferation...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2018) 145 (12): dev165498.
Published: 26 June 2018
... differentiation. During normal zebrafish craniofacial development, barx1 and then sox9a mark CNCs in pre-cartilage condensations ( Nichols et al., 2013 ; Barske et al., 2016 ). Sox9a then induces a number of cartilage differentiation genes, including those encoding for the extracellular matrix components...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (16): 2994–3005.
Published: 15 August 2017
... for craniofacial development, how genetic programs drive this regionalization remains incompletely understood. Here we use combinatorial labeling of zebrafish cranial neural crest-derived cells (CNCCs) to define global gene expression along the dorsoventral axis of the developing arches. Intersection of region...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (11): 2021–2031.
Published: 1 June 2017
.... Endothelin Craniofacial Neural crest cell Hinge and caps Knockout mouse Development of the vertebrate face requires the coordinated regulation of patterning cues throughout the pharyngeal arches of the developing embryo. Populated by cranial neural crest cells (NCCs) originating in the dorsal...
Journal Articles
Journal: Development
Development (2016) 143 (13): 2344–2355.
Published: 1 July 2016
... read and commented on it Funding This work was supported by a Cincinnati Children's Hospital Medical Center Trustee Award (to Y.L.); and by grants from the National Institutes of Health National Institute of Dental and Craniofacial Research [R03DE023864 to Y.L., R01DE013681 to R.J.]. Deposited...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (6): 1089–1094.
Published: 15 March 2015
... during pharyngeal pouch formation in the zebrafish head. Eph-ephrin PAK Branching morphogenesis Craniofacial Pharyngeal pouches Zebrafish During development, epithelial tissues undergo morphogenesis to form elaborately branched organs. Whereas epithelial cells are characterized...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (15): 3003–3012.
Published: 1 August 2014
.... Although phenotypically similar to talpid 3 , talpid 2 has a distinct facial phenotype and an unknown cellular, molecular and genetic basis. We set out to determine the etiology of the craniofacial phenotype of this mutant. We confirmed that primary cilia were disrupted in talpid 2 mutants. Molecularly, we...
Includes: Supplementary data