..., as well as the so-called fourth germ layer, the cranial neural crest. Over a century of experimental embryology and genetics have revealed an incredible diversity of cell types derived from each germ layer, signaling pathways and genes that coordinate craniofacial development, and how changes...

...Chukwuebuka Okeke; David Paulding; Alexa Riedel; Sandhya Paudel; Conrad Phelan; Camilla S. Teng; Lindsey Barske ABSTRACT Certain cranial neural crest cells are uniquely endowed with the ability to make skeletal cell types otherwise only derived from mesoderm. As these cells migrate...

... R01HL127717 F32HL156465 T32HL139430 T32GM088129 R01HL142704 R56HL142704 R01DE029014 R03DE025873 K01DE026561 R01HL118761 R01HL130804 Lats1 Lats2 Hippo signaling Cranial neural tube Cranial neural crest Craniofacial development Summary: Hippo signaling kinases LATS1 and LATS2...

... for craniofacial development, how genetic programs drive this regionalization remains incompletely understood. Here we use combinatorial labeling of zebrafish cranial neural crest-derived cells (CNCCs) to define global gene expression along the dorsoventral axis of the developing arches. Intersection of region...

...Jun Wang; Yang Xiao; Chih-Wei Hsu; Idaliz M. Martinez-Traverso; Min Zhang; Yan Bai; Mamoru Ishii; Robert E. Maxson; Eric N. Olson; Mary E. Dickinson; Joshua D. Wythe; James F. Martin The role of the Hippo signaling pathway in cranial neural crest (CNC) development is poorly understood. We used...

... progenitor loss. * Author for correspondence ( rich.schneider@ucsf.edu ) Competing interests The authors declare no competing financial interests. 14 6 2013 15 11 2013 © 2014. Published by The Company of Biologists Ltd 2014 Species-specific jaw size Cranial neural...

... by The Company of Biologists Ltd 2013 Neural crest Pillar cells Cre/loxP Zebrafish Cranial neural crest Gill The evolution of a true head has been proposed as a major step in the protochordate-vertebrate transition, enabling the shift from filter feeding to active predation ( Northcutt...

...Max Dougherty; George Kamel; Michael Grimaldi; Lisa Gfrerer; Valeriy Shubinets; Renee Ethier; Graham Hickey; Robert A. Cornell; Eric C. Liao Development of the palate in vertebrates involves cranial neural crest migration, convergence of facial prominences and extension of the cartilaginous...

... EMT function during both development and tumor metastasis. p53 plays multiple roles in the prevention of tumor development; however, its precise roles during embryogenesis are less clear. We have investigated the role of p53 in early cranial neural crest (CNC) development in chick and mouse embryos...

... and controls cell proliferation and apoptosis. Here we unravel an unexpected novel function for phb1 in Xenopus cranial neural crest (CNC) development. Xphb1 is maternally expressed; zygotically expressed neurula stage transcripts accumulate in the CNC and the neural tube. Knockdown of Xphb1 by antisense...

... order ventral to the embryonic vertebrate head region. They develop as a series of endodermal outpockets to the left and right of the developing pharynx, and are filled with ectomesenchymal cells derived from mesodermal and cranial neural crest cells. They are covered by surface ectoderm and they give...

...Catherine M. Drerup; Heather M. Wiora; Jacek Topczewski; Jill A. Morris This work reports the characterization and functional analysis of disrupted in schizophrenia 1 ( disc1 ), a well-documented schizophrenia-susceptibility gene, in zebrafish cranial neural crest (CNC). Our data demonstrated...

... cranial neural crest (CNC) cells of the midbrain and hindbrain region ( Le Douarin,1982 ). CNC forming the first pharyngeal arch (mandibular) is devoid of Hox gene expression, whereas cells contributing to the second(hyoid) and posterior (branchial, gill) arches display a nested pattern of Hox gene...

...Ariel Rinon; Shlomi Lazar; Heather Marshall; Stine Büchmann-Møller; Adi Neufeld; Hadas Elhanany-Tamir; Makoto M. Taketo; Lukas Sommer; Robb Krumlauf; Eldad Tzahor In the vertebrate head, mesoderm cells fuse together to form a myofiber,which is attached to specific cranial neural crest (CNC...

...Craig T. Miller; Lisa Maves; Charles B. Kimmel In vertebrate embryos, streams of cranial neural crest (CNC) cells migrate to form segmental pharyngeal arches and differentiate into segment-specific parts of the facial skeleton. To identify genes involved in specifying segmental identity...

... crest cells exhibit differential competence to respond to these signals as exemplified by the unique ability of cranial neural crest to form skeletal cell types. We show that in addition to differences in whether they respond to particular signals, cranial neural crest cells differ dramatically from...

... of discrete groups of cells from origin to destination and to compare neural crest migratory pathways in a basal vertebrate to those of gnathostomes. The results show that the general pathways of cranial neural crest migration are conserved throughout the vertebrates, with cells migrating in streams analogous...

.... This work was supported by grants from INSERM, MENRT, EC, ARC and AFM. References Anderson, C. B. and Meier, S. ( 1981 ). The influence of the metameric pattern in the mesoderm on migration of cranial neural crest cells in the chick embryo. Dev. Biol. 85 , 385 -402. Barrow, J. R...

.... ( 1993 ). Hoxa-2 mutant mice exhibit homeotic transformation of skeletal elements derived from cranial neural crest . Cell 75 , 1317 – 1331 . 10.1016/0092-8674(93)90619-2 Golding , J. P. , Trainor , P. , Krumlauf , R. and Gassmann , M. ( 2000 ). Defects in pathfinding...

... in which Et-1 in the environment of the postmigratory cranial neural crest specifies the lower jaw and other ventral arch fates. * Author for correspondence (e-mail: miller@uoneuro.uoregon.edu ) 09 08 2000 20 06 2000 © 2000 by Company of Biologists 2000 suc/et-1 is also...