..., further indicating that loss of Sp2 in early NSCs does not affect the earliest stages of corticogenesis ( Fig. S4 ). Taken together, in contrast to NPCs, at E10.5 Sp2 −/− NSCs complete roundup with similar timing to controls and generate the appropriate number of progeny by E11.5. The MADM system...

... forebrain development. Cux2 Lmx1a Cortical hem Corticogenesis Enhancer Telencephalon During forebrain development, neural progenitor cells give rise to many different types of neuronal and glial cells that form the various telencephalic structures and circuits. This vast cellular...

... to a marked expansion of a distinct proliferative cell population, basal to the SVZ. These cells constitute a novel neurogenic cell layer, similar to the OSVZ, and contribute to corticogenesis by heading for deeper cortical layers as a part of the cortical plate. Fig. 7. Schematic of the expansion...

... of radial glial cells (RGC) and intermediate precursors (IPC) was increased, expanding both populations, with greater effect on IPCs. Furthermore, cell cycle re-entry was increased during early corticogenesis, whereas cell cycle exit was augmented at middle stage. Consequently, neurogenesis was reduced...

...Keisuke Watanabe; Hirohide Takebayashi; Asim K. Bepari; Shigeyuki Esumi; Yuchio Yanagawa; Nobuaki Tamamaki During corticogenesis, the regulation of neuronal migration is crucial for the functional organization of the neocortex. Glutamatergic neurons are major excitatory components of the mammalian...

... was suppressed and that the neural stem cells continued to proliferate during early corticogenesis in the telencephalon of Fezf1 –/– Fezf2 –/– mice. These findings are consistent with the upregulation of Hes5 and the downregulation of neurogenin 2 observed in the Fezf1 –/– Fezf2 –/– telencephalon...

...Hilary A. North; Xiumei Zhao; Sharon M. Kolk; Meredith A. Clifford; Daniela M. Ziskind; Maria J. Donoghue Eph receptors are widely expressed during cerebral cortical development,yet a role for Eph signaling in the generation of cells during corticogenesis has not been shown. Cortical progenitor...

... and endows them with neurogenic properties. Using a Cre/ loxP -based approach, we studied the effect of conditional activation of two Pax6 isoforms, Pax6 and Pax6-5a ,on the corticogenesis of transgenic mice. We found that activation of either Pax6 or Pax6-5a inhibits progenitor proliferation...

... the lateral-to-medial gradient of neurogenesis ( Fig. 2 B). Along the anteroposterior axis, the wave of Svet1 -positive neurons reaches the outermost part of the cortical plate, following the anteroposterior gradient of corticogenesis (anterior first, posterior last; not shown). This ‘posterior delay’ takes...