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Keywords: Convergent extension
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Journal Articles
Journal: Development
Development (2022) 149 (13): dev200358.
Published: 1 July 2022
...-of-function experiments, we examine the roles of convergent extension and apical constriction, and define the role of the surface ectoderm during NTC. We show that NTC is a two-stage process with distinct spatiotemporal contributions of convergent extension and apical constriction at each stage. Convergent...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (22): dev192724.
Published: 18 November 2020
...Shiny Shengzhen Guo; Tiffany Y. K. Au; Sarah Wynn; Attila Aszodi; Danny Chan; Reinhard Fässler; Kathryn S. E. Cheah ABSTRACT The notochord drives longitudinal growth of the body axis by convergent extension, a highly conserved developmental process that depends on non-canonical Wnt/planar cell...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (7): dev152488.
Published: 29 March 2018
... by actomyosin-based oriented cell rearrangement and resulting dynamic tissue reshaping (convergent extension, CE). By labeling clusters of cells spanning the entire heart primordia, we show that the heart primordia converge toward the midline to form a narrow tube, while extending perpendicularly to rapidly...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (20): 3766–3776.
Published: 15 October 2017
... of the prosensory domain during development of the mouse cochlea. Inner ear Cochlear development Convergent extension Radial intercalation Live imaging Mouse The cellular mosaic that comprises the mammalian auditory sensory epithelium – the organ of Corti (OC) – is a remarkable example...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (9): 1725–1734.
Published: 1 May 2017
... during convergent extension in the Drosophila embryo. These studies demonstrate that planar polarity is rapidly established in a spatiotemporally regulated pattern that is dynamically remodeled in response to changes in cell orientation. These findings reveal an unexpected plasticity that maintains...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2017) 144 (4): 552–566.
Published: 15 February 2017
... malformations – ‘neural tube defects’ – that result when closure fails. The process of neural tube closure is complex and involves cellular events such as convergent extension, apical constriction and interkinetic nuclear migration, as well as precise molecular control via the non-canonical Wnt/planar cell...
Journal Articles
Journal: Development
Development (2015) 142 (8): 1516–1527.
Published: 15 April 2015
...Philipp Andre; Hai Song; Wantae Kim; Andreas Kispert; Yingzi Yang Mesoderm formation and subsequent anterior-posterior (A-P) axis elongation are fundamental aspects of gastrulation, which is initiated by formation of the primitive streak (PS). Convergent extension (CE) movements and epithelial...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (6): 1262–1271.
Published: 15 March 2013
..., cooperate to control PCP in the early mouse embryo. Two aspects of planar polarity can be analyzed quantitatively at cellular resolution in the mouse embryo: convergent extension of the axial midline; and posterior positioning of cilia on cells of the node. Analysis of the spatial distribution of brachyury...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (23): 4383–4394.
Published: 1 December 2012
... defects (VSDs) with ~15% penetrance; Fz2 +/− ;Fz7 −/− mice exhibit VSDs with ~50% penetrance and cleft palate with less than 10% penetrance; and Fz2 −/− ;Fz7 −/− mice exhibit convergent extension defects and mid-gestational lethality with 100% penetrance. When Fz2 and/or Fz7 mutations are combined...
Includes: Supplementary data
Journal Articles
Journal: Development
Series: Primer Series
Development (2012) 139 (21): 3897–3904.
Published: 1 November 2012
...Masazumi Tada; Carl-Philipp Heisenberg Body axis elongation represents a common and fundamental morphogenetic process in development. A key mechanism triggering body axis elongation without additional growth is convergent extension (CE), whereby a tissue undergoes simultaneous narrowing...
Journal Articles
Journal: Development
Development (2011) 138 (24): 5333–5343.
Published: 15 December 2011
... interaction with factors that determine its DNA target specificity. However, functional evidence linking TRIM28 to specific co-factors is scarce. chatwo , a hypomorphic allele of Trim28 , causes embryonic lethality and defects in convergent extension and morphogenesis of extra-embryonic tissues...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (7): 1321–1327.
Published: 1 April 2011
... RACK1 as a novel interaction partner of PTK7, a regulator of planar cell polarity that is necessary for neural tube closure. RACK1 is likewise required for Xenopus neural tube closure. Further, explant assays suggest that PTK7 and RACK1 are required for neural convergent extension. Mechanistically...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (22): 3801–3811.
Published: 15 November 2010
... the following morphogenetic mechanisms: (1) convergent extension in the neural plate (NP); (2) cell wedging along the anterior NP border; and (3) autonomous in-plane deformations outside the NP. Our numerical predictions agree relatively well with the observed morphology, as well as with our measured stress...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (3): 417–426.
Published: 1 February 2010
... in mesendoderm induction and gastrulation movements. Nodal activity is necessary for convergent extension in axial mesoderm and for head mesoderm migration. Using morpholino-mediated knockdown, we found that the Nodal ligands Xnr5 and Xnr6 are together required for mesendoderm induction, whereas Xnr1 and Xnr2...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (20): 3463–3474.
Published: 15 October 2009
... intercalation. Collectively, our data suggest that the distinct morphological features of the proliferative chondrocytes result from a convergent extension-like process that is regulated independently of chondrocyte maturation. Failure of column formation could also result from defects in cytokinesis,as shown...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (14): 2375–2384.
Published: 15 July 2009
... 14 5 2009 © 2009. 2009 Bleb Blebbing Myosin phosphatase Mypt1 (Ppp1r12a) Zebrafish Gastrulation Convergent extension Convergence Amoeboid RhoA Rock Metastasis Gastrulation is a tightly regulated series of cell rearrangements that establishes the vertebrate body plan...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (12): 2121–2131.
Published: 15 June 2009
...Ming Shao; Zhong-Zhen Liu; Cheng-Dong Wang; Hong-Yan Li; Clémence Carron; Hong-Wei Zhang; De-Li Shi The Glypican family of heparan sulfate proteoglycans regulates Wnt signaling and convergent extension (CE) in vertebrate embryos. They are predicted to be glycosylphosphatidylinositol (GPI)-tethered...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (4): 677–688.
Published: 15 February 2009
... suggest that it is the state of the actomyosin cell cortex rather than accumulating fibronectin that controls tissue stiffness in early amphibian embryos. * Author for correspondence (e-mail: ldavidson@engr.pitt.edu ) 1 12 2008 © 2009. 2009 Gastrulation Convergent extension...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (3): 383–392.
Published: 1 February 2009
... through its roles in mediating cell cohesion and Wnt/PCP signalling during zebrafish gastrulation. * Author for correspondence (e-mail: m.tada@ucl.ac.uk ) 19 11 2008 © 2009. 2009 Epiboly Convergent extension Planar cell polarity Celsr Flamingo Drosophila Zebrafish...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (1): 23–28.
Published: 1 January 2009
...Weiyang Shi; Sara M. Peyrot; Edwin Munro; Michael Levine Convergent extension (CE) is the narrowing and lengthening of an embryonic field along a defined axis. It underlies a variety of complex morphogenetic movements, such as mesoderm elongation and neural tube closure in vertebrate embryos...
Includes: Multimedia, Supplementary data