... function results in dramatic malformation of limb zeugopod skeletal elements, the radius/ulna and tibia/fibula, as well as transformation of the sacral region to a lumbar phenotype. Utilizing a Hoxa11eGFP knock-in allele, we show that Hox11 genes are expressed in the connective tissue fibroblasts...

... transformation. Multiple cell types are involved in limb regeneration; therefore, determining which cell types participate in distal transformation is important for understanding how the proximo-distal outcome of regeneration is achieved. We show that connective tissue-derived blastema cells obey the rule...

... of these cells for regeneration has not been tested. Connective tissue fibroblasts also are likely to play a role in regeneration, as connective tissue fibrosis is a hallmark of regenerating muscle. However, the lack of molecular markers for these fibroblasts has precluded an investigation of their role. Using...

...Gabrielle Kardon In March 2011, researchers met for the second Batsheva Seminar on Integrative Perspectives on the Development of the Musculoskeletal System. This meeting was a unique opportunity for researchers working on muscle, connective tissue, tendons, ligaments and bone to discuss...

...Sam J. Mathew; Jody M. Hansen; Allyson J. Merrell; Malea M. Murphy; Jennifer A. Lawson; David A. Hutcheson; Mark S. Hansen; Melinda Angus-Hill; Gabrielle Kardon Muscle and its connective tissue are intimately linked in the embryo and in the adult, suggesting that interactions between these tissues...

... by differentiating muscles and cartilage to establish the connections between tendon primordia and their respective musculoskeletal counterparts, leading to the formation of an interconnected and functionally integrated musculoskeletal system. The connective tissues comprise a heterogeneous group of tissues...

... 2007. 2007 Scleraxis Tendon Connective tissue Mouse mutant The musculoskeletal system consists of three major components: skeletal tissue, which provides structural support and defines the mechanical units;muscular tissue, which generates force; and tendons, which transmit...

... for correspondence 01 12 1994 © 1995 by Company of Biologists 1995 connective tissue tendons muscle homeobox embryogenesis murine limb splotch The development of the vertebrate limb is a popular system for studying the mechanisms controlling patterning and morpho-genesis...

... to form at least two cell types; myocytes that resembled fetal skeletal muscle cells and loose connective tissue cells that secreted large amounts of type I collagen. These results suggest that skeletal myocytes and connective tissue share a common precursor and that stem cells with limited but multiple...

... for the axolotl forelimb. We show that the complex forms autonomously in muscleless axolotl limb regenerates produced from a cuff of unirradiated dermis surrounding an irradiated limb stump, and persists for up to a year after amputation. The pattern of other connective tissue structures, including the skeleton...