... Isl1 , at the chromosome 13 locus. Using single and double conditional knockout mice, we confirm the countervailing actions of each gene, and validate in vitro a crucial role for two single nucleotide polymorphisms in the 5′UTR of Isl1 , one of which yields a novel E-box, mediating the repressive...

... and the primitive endoderm are host derived ( Nagy et al., 1993 ). Thus, any genetic modification in the host embryo is maintained not only in the trophoblast, but also in the primitive endoderm lineage. Although a large set of conditional knockout mouse models are available from public repositories...

...-Golgin GMAP-210 reveals that the skeletal phenotype in achondrogenesis type-1A, which is caused by mutations in GMAP-210, is solely due to impaired protein trafficking by chondrocytes. GMAP-210 Achondrogenesis type 1A Conditional knockout Golgin Cartilage Proteomics The evolution...

... for the assembly of TFIID and SAGA complexes in the embryo but in its absence, global transcription is not affected in the presomitic mesoderm at E9.5. RNA polymerase II TATA binding protein Presomitic mesoderm Paraxial mesoderm Conditional knockout Proteomic Mouse In mouse, the posterior part...

... ) * These authors contributed equally to this work Competing interests statement The authors declare no competing financial interests. 10 1 2013 © 2013. Published by The Company of Biologists Ltd Wnt1 Conditional knockout Dopamine neurons Genetic inducible fate mapping...

... Sox9 Chondrocytes Collagen Conditional knockout Transcriptional regulation Mouse During development, the limb skeleton is created through endochondral bone formation. Mesenchymal cells initially undergo condensation, which is followed by the differentiation of prechondrogenic cells within...

... not essential for enteric crest-derived cells to enter the neuronal lineage; however, it is required to enable them to complete neuronal differentiation. The effects on sympathetic and enteric neuronal development of the conditional knockout of Hand2 appear to differ. Whereas Hu immunoreactivity...

... by colonising the hindgut from the pelvic plexus in a caudorostral wave ( Kapur,2000 ; Druckenbrod and Epstein,2005 ). Enteric nervous system β1 integrins Neural crest Migration Conditional knockout Hirschsprung's disease Mouse © 2006. 2006 3 3 2006 * Present...

... expressing Cre-ERT2 can be efficiently used to perform time-specific excision of a target gene by a Cre/ loxP -based conditional knockout system(reviewed by Metzger et al.,2005 ). We tested the efficiency of the Cre-ERT2 recombinase in mediating excision at the Hoxa2 locus by directly monitoring...

...,and thus plays a crucial role in determining the relative composition of excitatory and inhibitory neurons of the cerebral cortex. Recently, an analysis of the role of Shh signaling on the initial patterning of the telencephalon was made using a FoxG1-Cre:Smoothened Fl/Fl conditional knockout, which...

... 2004 ©2004. 2004 Integrin Peripheral nervous system Neural crest cells Conditional knockout The ontogeny of neural crest cells (NCC) is a major morphogenetic process involving various biological steps, such as epithelium-mesenchyme transition,cell migration and cell aggregation...