... regulatory program. Lineage size Cell cycle Asymmetric division Combinatorial control Nervous system development Evolution of the CNS The central nervous system (CNS) is a defining feature of bilaterally symmetric animals (bilateria), and can be generally subdivided into the brain...

... to control lineage progression. Lineage tree Cell cycle Asymmetric division Combinatorial control Notch During nervous system development, neural progenitor cells initially divide symmetrically to expand the progenitor pool. Subsequently, they switch to dividing asymmetrically to generate...

... University, Teaneck, NJ 07666, USA. Competing interests statement The authors declare no competing financial interests. 25 7 2011 © 2011. Combinatorial control Embryogenesis Repression Transcription Drosophila Establishing temporal and spatial gene...