1-10 of 10
Keywords: Coloboma
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles
In collection:
Human development
Journal: Development
Development (2020) 147 (24): dev193649.
Published: 28 December 2020
...Aara Patel; Glenn Anderson; Gabriel L. Galea; Monika Balys; Jane C. Sowden ABSTRACT Ocular coloboma is a congenital eye malformation, resulting from a failure in optic fissure closure (OFC) and causing visual impairment. There has been little study of the epithelial fusion process underlying...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2020) 147 (21): dev187047.
Published: 13 July 2020
... through which vasculature enters the eye and ganglion cell axons exit. Although many factors have been identified that function during CF closure, the molecular and cellular mechanisms mediating this process remain poorly understood. Failure of CF closure results in colobomas. Recently, MITF was shown...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (22): dev165068.
Published: 19 November 2018
... process, disruptions of which can lead to coloboma, a birth defect causing visual impairment. Here, we use four-dimensional imaging, cell tracking, and molecular genetics in zebrafish to define the cell movements underlying normal optic fissure and stalk formation. We determine how these events...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (17): 3021–3032.
Published: 1 September 2015
... a subset of RPE cells and/or exhibit coloboma. Loss of RPE in yap mutants is exacerbated in combination with taz ( wwtr1 ) mutant alleles such that, when Yap and Taz are both absent, optic vesicle progenitor cells completely lose their ability to form RPE. The mechanism of Yap-dependent RPE cell type...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (13): 2711–2723.
Published: 1 July 2013
..., ocular coloboma. Defective FGF signaling does not abrogate Shh or BMP signaling, nor does it affect axial patterning of the optic vesicle. Instead, FGF signaling regulates Mitf and Pax2 in coordinating the closure of the optic fissure and optic disc specification, which is necessary for the outgrowth...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (21): 3567–3576.
Published: 1 November 2008
...Chunqiao Liu; Jeremy Nathans Microphthalmia, coloboma and persistent fetal vasculature within the vitreous cavity are among the most common human congenital ocular anomalies,and each has been associated with a variety of genetic disorders. Here we show that, in the mouse, loss of frizzled 5 (Fz5...
Journal Articles
Journal Articles
Journal: Development
Development (2003) 130 (5): 955–968.
Published: 1 March 2003
... 11 2002 © 2003. 2003 Zebrafish Vax Eye Optic stalk Coloboma fgf hedgehog The vertebrate eye originates from cells of the eye field located within the anterior neural plate. Following neural tube formation, prospective eye tissue evaginates from the brain to form...
Journal Articles
Journal Articles
Journal: Development
Development (1987) 99 (4): 501–508.
Published: 1 April 1987
...C. L. Scholtz; K. K. Chan A study of the development of the eye in the cinnamon mouse, homozygous for the gene for microphthalmia (mi) , has shown that the microphthalmia is due to failure of secondary vitreous formation associated with a coloboma. The retina is dystrophic but there is a residual...