... eventually results in its docking at the posterior Par3 patch ( Fig. 8 ). Fig. 8. Summary of BB behavior and Par3 localization during early and late stages of development in the FP of wt and vangl2 zebrafish mutants. In wt embryos during 4-8s stages, the BBs, which anchor a growing cilium, shuttle...

..., is identified as a master gene in hindbrain choroid plexus patterning and multiciliogenesis. Choroid plexus Patterning Development Hindbrain Wnt BMP Cilium Multiciliated cells Multiciliated epithelium Microvilli Zfp423 ZNF423 Joubert syndrome JS19 Hydrocephalus The choroid plexus...

... are the two key regulators for the establishment of amphioxus left-right asymmetry, likely representing an evolutionarily conserved mechanism in deuterostomes. Amphioxus Left-right asymmetry Embryonic development Hh signalling Cilium Bilateral symmetry is a fundamental feature of many animal...

...Jinling Liu; Huiqing Zeng; Aimin Liu Hedgehog signaling is crucial for vertebrate development and physiology. Gli2, the primary effector of Hedgehog signaling, localizes to the tip of the primary cilium, but the importance of its ciliary localization remains unclear. We address the roles of Gli2...

...Neil A. Duldulao; Sunjin Lee; Zhaoxia Sun arl13b was initially cloned as the novel cystic kidney gene scorpion ( sco ) in zebrafish and was shown to be required for cilia formation in the kidney duct. In mouse, a null mutant of Arl13b shows abnormal ultrastructure of the cilium and defective sonic...

... here are excellent candidates for novel human PKD genes. PKD Cilium Zebrafish † Author for correspondence (e-mail: nhopkins@mit.edu ) * Present address: Department of Genetics, Yale University School of Medicine, 333 Cedar Street, NSB-393, P.O. Box 208005, New Haven, CT 06520,USA...