... ossification are tightly controlled by growth factors, morphogens, hormones, and transcriptional factors that engage in crosstalk with Hippo-YAP1/TAZ signaling. Here, we generated tamoxifen-inducible, chondrocyte-specific Mob1a/b -deficient mice and show that hyperactivation of endogenous YAP1/TAZ impairs...

... into chondrocytes and tenocytes/ligamentocytes to form the junction between cartilage and tendon/ligament. Sox9 lineage tracing in the Scx + domain revealed that Scx + progenitors can be subdivided into two distinct populations with regard to their Sox9 expression history: Scx + / Sox9 + and Scx + / Sox9...

... (HIF1α) as a central component in a mechanism that underlies collagen hydroxylation and secretion by hypoxic cells. We show that Hif1a loss of function in growth plate chondrocytes arrests the secretion of extracellular matrix proteins, including collagen type II. Reduced collagen hydroxylation...

...Weiguang Wang; Na Lian; Yun Ma; Lingzhen Li; Richard C. Gallant; Florent Elefteriou; Xiangli Yang Atf4 is a leucine zipper-containing transcription factor that activates osteocalcin ( Ocn ) in osteoblasts and indian hedgehog ( Ihh ) in chondrocytes. The relative contribution of Atf4 in chondrocytes...

...Daisuke Ikegami; Haruhiko Akiyama; Akira Suzuki; Takashi Nakamura; Toru Nakano; Hideki Yoshikawa; Noriyuki Tsumaki During endochondral bone formation, Sox9 expression starts in mesenchymal progenitors, continues in the round and flat chondrocyte stages at high levels, and ceases just prior...

... in the regulation of the chondrocyte phenotype. Expression ofβ-catenin was high in prechondrogenic mesenchymal cells, but significantly decreased in differentiated chondrocytes both in vivo and in vitro. Accumulation of β-catenin by the inhibition of glycogen synthase kinase-3β with LiCl inhibited chondrogenesis...

... and differentiation in frontonasal mass cultures suggest that either these two processes are independently stimulated to the same extent or a single subpopulation of cells is stimulated to divide and differentiate into chondrocytes. The different responses of the populations of individual facial primordia to growth...

...Stanislaw Moskalewski; Jacek Malejczyk ABSTRACT Isolated syngeneic epiphyseal chondrocytes transplanted into a muscle formed cartilage in which matrix resorption and endochondral ossification began at the end of the second week after transplantation. After 56 days cartilage was converted...

...Shinobu Nakanishi; Edwin M. Uyeki ABSTRACT Benzamide, an inhibitor of (ADP-ribose) transferase, augmented chondrocytic differentiation of chick limb bud mesenchymal cells in micromass cultures; the incorporation of 35 SO 4 2- into the trichloroacetic-acid-insoluble constituents of cell masses...