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Keywords: Chondrocyte differentiation
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Journal Articles
Journal Articles
Journal: Development
Development (2012) 139 (16): 2988–2998.
Published: 15 August 2012
... chondrogenesis. These results identify MLTK as a novel key regulator of chondrogenesis, and reveal its action mechanism in chondrocyte differentiation during embryonic development. Neural crest cells, which are generated at the lateral edge of the neural plate, migrate extensively and differentiate...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (21): 3917–3928.
Published: 1 November 2007
... studies on a variety of cell types have reported that hypoxia has an inhibitory effect on cell differentiation. In order to investigate the mechanism that supports chondrocyte differentiation under hypoxic conditions, we inactivated the transcription factor hypoxia-inducible factor 1α (HIF1α) in mouse...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2002) 129 (12): 2977–2986.
Published: 15 June 2002
... regulates terminal chondrocyte differentiation through the PTH/PTHrP receptor (PPR). However, the roles of PTHrP and Ihh in regulating earlier steps in chondrocyte differentiation are unclear. We present novel mouse models with PPR abnormalities that help clarify these roles. In mice with chondrocyte...
Journal Articles
Journal: Development
Development (2000) 127 (14): 3141–3159.
Published: 15 July 2000
... prehypertrophic to hypertrophic chondrocytes, while mesenchymal cells immediately surrounding the early cartilage template form the perichondrium. Recently, members of the Wnt family of secreted signaling molecules have been implicated in regulating chondrocyte differentiation. We find that Wnt-5a, Wnt-5b and Wnt...