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Keywords: Chondrocyte
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Journal Articles
Journal: Development
Development (2022) 149 (11): dev196220.
Published: 6 June 2022
... cartilage that expressed chondrocyte hypertrophy markers and readily underwent mineralization after ectopic transplantation. In contrast, the slowly growing GDF5 + cells derived from SOX9 + cells formed cartilage that tended to express low to undetectable levels of chondrocyte hypertrophy markers...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (2): dev193409.
Published: 25 January 2021
...Joanna Smeeton; Natasha Natarajan; Arati Naveen Kumar; Tetsuto Miyashita; Pranidhi Baddam; Peter Fabian; Daniel Graf; J. Gage Crump ABSTRACT The regulated expansion of chondrocytes within growth plates and joints ensures proper skeletal development through adulthood. Mutations in the transcription...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (14): dev185777.
Published: 20 July 2020
... brain and limbs . Mech. Dev.   77 , 9 - 18 . 10.1016/S0925-4773(98)00131-2 Choocheep , K. , Hatano , S. , Takagi , H. , Watanabe , H. , Kimata , K. , Kongtawelert , P. and Watanabe , H. ( 2010 ). Versican facilitates chondrocyte differentiation and regulates joint...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (13): dev162396.
Published: 9 July 2018
..., whereas mice lacking the Insig genes in mesenchymal progenitors had short limbs, but normal chondrogenesis. Mice lacking Scap in chondrocytes showed severe dwarfism, with ectopic hypertrophic cells, whereas deletion of Insig genes in chondrocytes caused a mild dwarfism and shortening of the hypertrophic...
Journal Articles
Journal: Development
Development (2016) 143 (15): 2706–2715.
Published: 1 August 2016
... developmental and regenerative bone formation and providing niche microenvironments for various cell types. Bone Angiogenesis Blood vessels Endothelial cell Chondrocyte Osteoblast Osteoclast The skeletal system – a framework of bones and connective tissues – provides essential structural...
Journal Articles
Journal: Development
Development (2016) 143 (13): 2367–2375.
Published: 1 July 2016
... and the Yap/Taz Hippo effectors. Fat4 Dchs1 Vertebrae Somite Chondrocyte Yap1 Taz (Wwtr1) Mouse Fat4 and Dchs1 are protocadherins that act as a receptor-ligand pair to play key roles during embryonic development. Gene inactivation of either Fat4 or Dchs1 in mice results in a wide...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (12): 2066–2076.
Published: 15 June 2016
... bone regeneration in the lower jaw of adult zebrafish, we show that chondrocytes are crucial for generating thick bone during repair. During jawbone regeneration, we find that chondrocytes co-express genes associated with osteoblast differentiation and produce extensive mineralization, which...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (10): 1811–1822.
Published: 15 May 2016
... showed growth plate defects and an arrest in chondrocyte proliferation. We provide genetic evidence of a non-cell-autonomous feedback pathway regulating Fgf9 , Fgf18 and Pthlh expression, which led to increased expression and signaling of Fgfr3 in growth plate chondrocytes and suppression of chondrocyte...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (4): 648–657.
Published: 15 February 2016
... expand and are resorbed by osteoclasts then replaced by osteoblastic bone formation. Ephrin B2 is a receptor tyrosine kinase expressed by osteoblasts and growth plate chondrocytes that promotes osteoblast differentiation and inhibits osteoclast formation. We investigated the role of ephrin B2...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (14): 2848–2854.
Published: 15 July 2014
... associated with severe delays in chondrocyte hypertrophy and bone formation. The growth reduction of cartilage is not due to changes in chondrocyte proliferation or survival, but is caused by a reduction in cell size and in the amount of cartilage matrix. Metabolic labeling reveals a notable deficit...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (12): 2597–2610.
Published: 15 June 2013
... there is access to appropriate tissue and sufficient numbers of articular chondrocytes. Embryonic stem cells (ESCs) represent a potentially unlimited source of chondrocytes and tissues as they can generate a broad spectrum of cell types under appropriate conditions in vitro . Here, we demonstrate that mouse ESC...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (6): 1198–1212.
Published: 15 March 2012
... and chondro-osteo progenitor cell populations, there has yet to be a true examination of Notch signaling specifically within developing and committed chondrocytes, or a determination of whether cartilage and bone formation are regulated via RBPjκ-dependent or -independent Notch signaling mechanisms...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (23): 3991–4000.
Published: 1 December 2009
... hedgehog mutants. The other derives from chondrocytes and requires higher levels of Hh signalling to form. This latter population develops significantly earlier in mutants with increased Hh signalling, leading to premature endochondral ossification, and also fails to differentiate in Indian hedgehog...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (20): 3463–3474.
Published: 15 October 2009
... interferes with signal reception by chondrocytes as evidenced by delayed maturation. Second, the proliferative chondrocytes, although present, fail to flatten and arrange into columns. We present evidence that the abnormal organization of mutant proliferative chondrocytes results from errors in cell...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (10): 1697–1706.
Published: 15 May 2009
... signaling, BrdU incorporation exhibited a significant reduction in chondrocyte proliferation. Direct measurements of Ihh binding to defined GAG chains demonstrated that Ihh interacts with CS, particularly chondroitin-4-sulfate. Furthermore,co-immunoprecipitation experiments showed that Ihh binds...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (7): 1083–1092.
Published: 1 April 2009
...Yuwei Li; Andrew T. Dudley Bone growth is driven by cell proliferation and the subsequent hypertrophy of chondrocytes arranged in columns of discoid cells that resemble stacks of coins. However, the molecular mechanisms that direct column formation and the importance of columnar organization...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (22): 3775–3787.
Published: 15 November 2008
...Kathrin Laue; Martina Jänicke; Nikki Plaster; Carmen Sonntag; Matthias Hammerschmidt Skeletal syndromes are among the most common birth defects. Vertebrate skeletogenesis involves two major cell types: cartilage-forming chondrocytes and bone-forming osteoblasts. In vitro, both are under...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (17): 2845–2854.
Published: 1 September 2008
... into mandibular defects they differentiated into chondrocytes. A mismatch between the Hox gene expression status of the host and donor cells might be responsible for this aberration in bone repair. We found that initially,mandibular skeletal progenitor cells are Hox-negative but that they adopt a Hoxa11 -positive...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (16): 2903–2912.
Published: 15 August 2007
... of the primary cilium. The growth plate of Evc -/- mice shows delayed bone collar formation and advanced maturation of chondrocytes. Indian hedgehog( Ihh ) is expressed normally in the growth plates of Evc -/- mice, but expression of the Ihh downstream genes Ptch1 and Gli1 was markedly decreased. Recent studies...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (23): 5249–5260.
Published: 1 December 2005
... the onset of hypertrophic differentiation, and it regulates chondrocyte proliferation and ossification of the perichondrium independently of PTHrP. To investigate how the Ihh signal is translated in the different target tissues, we analyzed the role of the zinc-finger transcription factor Gli3, which acts...
Includes: Supplementary data