...Natasha M. Tian; Thomas Pratt; David J. Price Mammalian binocular vision relies on the divergence of retinal ganglion cell axons at the optic chiasm, with strictly controlled numbers projecting contralaterally and ipsilaterally. In mouse, contralateral projections arise from the entire retina...

... of the contralateral projecting RGC axons at the chiasm,indicating that midline-derived Shh participates in funnelling contralateral visual fibres in this region. Furthermore, interference with Shh signalling in the RGCs themselves causes abnormal growth and navigation of contralateral projecting axons in the proximal...

... transcription factor expressed in the brain, eye and fin buds. We show that bel(lhx2) function is required for patterning in the ventral forebrain and eye, and that loss of bel function leads to alterations in regulatory gene expression, perturbations in axon guidance factors, and the absence of an optic chiasm...

... † Present address: Biology Department, Williams College, Williamstown, MA 01267, USA 3 6 2005 ©2005. 2005 Zebrafish Cyclopamine Morpholino Axon guidance POC Chiasm Gfap Glia hedgehog slit you-too In bilateral organisms, some axons cross the midline of the CNS...