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Keywords: Chemokine
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Journal Articles
Journal: Development
Development (2020) 147 (24): dev192971.
Published: 21 December 2020
... is similarly affected by mutations in the chemokine receptor gene, cxcr4b , suggesting it is a potential Neurog1 target gene. We find that Neurog1 directly regulates cxcr4b through an E-box cluster located just upstream of the cxcr4b transcription start site. Our results suggest that proneural transcription...
Journal Articles
Journal: Development
Development (2020) 147 (12): dev187815.
Published: 17 June 2020
...Gillian J. Wilson; Ayumi Fukuoka; Samantha R. Love; Jiwon Kim; Marieke Pingen; Alan J. Hayes; Gerard J. Graham ABSTRACT Macrophages are key regulators of developmental processes, including those involved in mammary gland development. We have previously demonstrated that the atypical chemokine...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (2): dev181545.
Published: 17 January 2020
... and dilated lymphatic vessels accompanied with increased proliferation and decreased apoptosis in the lymphatic capillaries. Comprehensive DNA microarray analysis of the causes of in vivo phenotypes in FOXO1-deficient mice revealed that the gene encoding C-X-C chemokine receptor 4 (CXCR4) was the most...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (14): 2652–2662.
Published: 15 July 2017
... have opposing roles in transcriptional regulation of components of the Cxcr4-chemokine signaling pathway. The chemokine pathway, in turn, directs the posterior outgrowth of dHb efferents toward the IPN and, when disrupted, results in ectopic, anteriorly directed axonal projections. The results define...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (22): 4199–4205.
Published: 15 November 2014
...John Wang; Holger Knaut Chemokines are a group of small, secreted molecules that signal through G protein-coupled receptors to promote cell survival and proliferation and to provide directional guidance to migrating cells. CXCL12 is one of the most evolutionary conserved chemokines and signals...
Journal Articles
Journal: Development
Development (2014) 141 (3): 661–673.
Published: 1 February 2014
... and then tangentially, whereas neurons destined for the medial VTA undergo primarily radial migration. We show that tangentially migrating dopaminergic neurons express the components of the reelin signaling pathway, whereas dopaminergic neurons in their initial, radial migration phase express CXC chemokine receptor 4...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (14): 2909–2914.
Published: 15 July 2011
... cells (PGCs) from their site of specification towards their target is a valuable model for investigating directed cell migration within the complex environment of the developing embryo. In several vertebrates, PGC migration is guided by Cxcl12, a member of the chemokine superfamily. Interestingly, two...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (9): 1717–1726.
Published: 1 May 2011
..., in controlling angiogenesis. We show here that both pathways similarly act during vascularization of the zebrafish central nervous system. In addition, we find that chemokine signaling specifically controls arterial-venous network formation in the brain. Zebrafish mutants for the chemokine receptor cxcr4a or its...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (9): 1705–1715.
Published: 1 May 2011
... sprouting from the primordial hindbrain channels gives rise to angiogenic central arteries that penetrate into and innervate the hindbrain. The chemokine receptor cxcr4a is expressed in migrating endothelial cells of the primordial hindbrain channels, whereas its ligand cxcl12b is expressed in the hindbrain...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (11): 1919–1928.
Published: 1 June 2009
... migration of pontine neurons are poorly understood. Here, we report that a chemokine SDF1 (also known as CXCL12) derived from the meningeal tissue regulates the migratory pathways of PCN. PCN are chemoattracted by the meningeal tissue, an effect that is mimicked by an SDF1 source. Analysis of knockout mice...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2003) 130 (22): 5519–5532.
Published: 15 November 2003
... and begin to migrate into the maternal tissue. We previously reported that dipeptidyl peptidase IV(DPPIV) is expressed on EVTs in the proximal part of cell column and is involved in the inhibition of their migration. Because DPPIV has been shown to degrade several chemokines, we examined possible roles...
Journal Articles
Journal: Development
Development (2003) 130 (18): 4279–4286.
Published: 15 September 2003
.... Mech. Dev. 91 , 61 -68. Bacon, K., Baggiolini, M., Broxmeyer, H., Horuk, R., Lindley,I., Mantovani, A., Maysushima, K., Murphy, P., Nomiyama, H., Oppenheim, J. et al. ( 2002 ). Chemokine/chemokine receptor nomenclature. J. Interferon Cytokine Res. 22 , 1067 -1068. Bleul, C. C., Farzan, M...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2002) 129 (18): 4249–4260.
Published: 15 September 2002
... important events in dentate gyrus morphogenesis. In searching for candidate ligands that may regulate dentate granule cell migration, we found that SDF1, a chemokine that regulates cerebellar and leukocyte migration, and its receptor CXCR4 are expressed in patterns that suggest a role in dentate granule...
Journal Articles
Journal: Development
Development (2001) 128 (11): 1971–1981.
Published: 1 June 2001
...Robyn S. Klein; Joshua B. Rubin; Hilary D. Gibson; Elliot N. DeHaan; Xavier Alvarez-Hernandez; Rosalind A. Segal; Andrew D. Luster The chemokine SDF-1α (CXC12) and its receptor CXCR4 have been shown to play a role in the development of normal cerebellar cytoarchitecture. We report here that SDF-1α...