... mouse corticogenesis, radial glial cells (RGCs), the principal progenitor cells in the cerebral cortex, can divide asymmetrically in the ventricular zone (VZ) to produce intermediate progenitor cells (IPCs) ( Götz and Barde, 2005 ; Sessa et al., 2008 ). IPCs move to the subventricular zone (SVZ) where...

...Matthieu X. Moreau; Yoann Saillour; Andrzej W. Cwetsch; Alessandra Pierani; Frédéric Causeret ABSTRACT In the developing cerebral cortex, how progenitors that seemingly display limited diversity end up producing a vast array of neurons remains a puzzling question. The prevailing model suggests...

...Sonia Najas; Isabel Pijuan; Anna Esteve-Codina; Susana Usieto; Juan D. Martinez; An Zwijsen; Maria L. Arbonés; Elisa Martí; Gwenvael Le Dréau ABSTRACT The growth and evolutionary expansion of the cerebral cortex are defined by the spatial-temporal production of neurons, which itself depends...

... in the developing cerebral cortex. The neurogenic ability of neural progenitors is also dynamically controlled by spatial and temporal information during cortical development. At the early stages of cortical development, neural progenitors are proliferative, undergoing symmetric cell divisions. In contrast...

... neuronal connections via selective axon guidance. The EMX transcription factors are essential for early patterning of the cerebral cortex, but whether EMX1 mediates interhemispheric connectivity by controlling corpus callosum formation remains unclear. Here, we demonstrate that in mice on the C57Bl/6...

..., such as non-human primates ( Wunderlich et al., 2014 ). This might shed further light on the evolutionary conservation and divergence of various other aspects of brain development, such as the gyration patterns of the cerebral cortex that have been independently acquired in multiple mammalian lineages ( Lui...

...Peter Kirwan; Benita Turner-Bridger; Manuel Peter; Ayiba Momoh; Devika Arambepola; Hugh P. C. Robinson; Frederick J. Livesey A key aspect of nervous system development, including that of the cerebral cortex, is the formation of higher-order neural networks. Developing neural networks undergo...

... using the mouse embryonic cerebral cortex as an experimental model. We combined atomic force microscopy measurements of tissue and cellular stiffness with immunostaining of specific markers of neural differentiation to correlate the value of stiffness with the characteristic features of tissues...

... Electroporation Cerebral cortex Wulst Dorsal ventricular ridge The goal of cell lineage analysis is to provide information on the number, distribution, phenotype and functional integration of all cells derived from the same single embryonic stem cell or progenitor population ( Buckingham...

... anterior subventricular zone . J. Neurosci. 21 , 3092 – 3103 . Costa M. R. , Kessaris N. , Richardson W. D. , Götz M. , Hedin-Pereira C. ( 2007 ). The marginal zone/layer I as a novel niche for neurogenesis and gliogenesis in developing cerebral cortex . J. Neurosci...

... Neuronal migration Neuronal identity Axon pathfinding Pyramidal neuron Neuronal circuits Cerebral cortex The cerebral cortex, an extensive sheet of neural tissue at the most superficial part of the cerebral hemispheres, is involved in a variety of higher cognitive, emotional...

... Competing interests statement The authors declare no competing financial interests. 16 8 2011 © 2011. Radial migration Cerebral cortex Callosal projection neurons Dendrite morphology COUP-TFI Rnd2 Mouse The mammalian neocortex has undergone pronounced...

.... Neurosci. 8 , 945 - 974 . Mizutani K. , Saito T. ( 2005 ). Progenitors resume generating neurons after temporary inhibition of neurogenesis by Notch activation in the mammalian cerebral cortex . Development 132 , 1295 - 1304 . Molyneaux B. J. , Arlotta P. , Menezes...

...Jeremy N. Pulvers; Wieland B. Huttner The extent of apoptosis of neural progenitors is known to influence the size of the cerebral cortex. Mouse embryos lacking Brca1 , the ortholog of the human breast cancer susceptibility gene BRCA1 , show apoptosis in the neural tube, but the consequences...

... University, Nashville, TN 37232, USA 17 2 2009 © 2009. 2009 Mouse Olfactory epithelium TGFβ Follistatin p21Cip1 Fgf8 Neuronal progenitor Neurogenesis Mash1 Ngn1 Sox2 Olfactory receptor neuron Cerebral cortex Gene dosage Forkhead or Fox proteins comprise a large...

...Anne K. Voss; Joanne M. Britto; Mathew P. Dixon; Bilal N. Sheikh; Caitlin Collin; Seong-Seng Tan; Tim Thomas Neuronal migration is integral to the development of the cerebral cortex and higher brain function. Cortical neuron migration defects lead to mental disorders such as lissencephaly...

..., 10 Rue Vauquelin, 75231 Paris Cedex 05, France 22 5 2007 © 2007. 2007 Cerebral cortex Neocortex GABAergic neurons Nkx2.1 Tbr1 Darpp-32 Tangential migration DVR MGE LGE Turtle Most parts of the brain are remarkably conserved across amniotes, a group including...

...Toshio Ohshima; Motoyuki Hirasawa; Hidenori Tabata; Tetsuji Mutoh; Tomoko Adachi; Hiromi Suzuki; Keiko Saruta; Takuji Iwasato; Shigeyoshi Itohara; Mistuhiro Hashimoto; Kazunori Nakajima; Masaharu Ogawa; Ashok B. Kulkarni; Katsuhiko Mikoshiba The mammalian cerebral cortex consists of six layers...

... in expression of cortical lamination markers. The alterations in cortical cytoarchitecture result in behavioral abnormalities suggestive of a deficient processing of visual and spatial memory cues in the cerebral cortex of adult Zbtb20 transgenic mice. Overall,our in vivo data suggest that Zbtb20 functions...

..., neuronal subtype composition was severely disturbed at late developmental stages (E18)in the cortex of the laminin γ1III4 -/- mice. Thus, although BM attachment seems dispensable for precursor cells, an intact BM is required for adequate neuronal composition of the cerebral cortex. * Author...