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Keywords: Cerebellum
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Journal Articles
Journal: Development
Development (2020) 147 (19): dev190603.
Published: 09 October 2020
...Tsubasa Itoh; Miki Takeuchi; Marina Sakagami; Kazuhide Asakawa; Kenta Sumiyama; Koichi Kawakami; Takashi Shimizu; Masahiko Hibi ABSTRACT Neurons in the inferior olivary nuclei (IO neurons) send climbing fibers to Purkinje cells to elicit functions of the cerebellum. IO neurons and Purkinje cells...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (21): dev189019.
Published: 03 August 2020
... the postnatal development and function of cerebellar microglia, contributing to profound defects in developmental synaptic pruning and connectivity in the cerebellum. Specifically, we found that lack of NPC1 in mice reduced radial migration, increased proliferation and impaired differentiation of microglial...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (21): dev188078.
Published: 15 June 2020
.... ImageJ software was used to quantify the western blot data. The Olympus IX73 microscope and CellSens software were used for cerebellum size quantification. The cerebellum EGL length was normalized to bodyweight. Author contributions Conceptualization: P.M., Y.L., B.M.; Methodology: P.M., T.A...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (5): dev158782.
Published: 08 March 2018
..., microtubules dynamically bind to nesprins in the nuclear envelope via kinesin-1 and dynein, and induce sharpening, rotation and translocation of the nucleus independently of actin. Neuronal migration Cerebellum Nucleus Nesprin Microtubules Kinesin-1 Mouse During mammalian brain development...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (2): dev159400.
Published: 17 January 2018
... preferentially migrate tangentially under the pial surface in a netrin 1-rich domain ( Stanco and Anton, 2013 ). This occurs in the case of the pontine nucleus, one of the four hindbrain precerebellar nuclei that contain neurons projecting to the cerebellum. Pontine neurons are born in the rhombic lip, a dorsal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (2): dev150375.
Published: 17 January 2018
... of Biologists Ltd 2018 Highlighted Article: The conditional ablation of Slit proteins and Robo receptors in precerebellar neurons and floor plate reveals that, in the mouse, the migration of hindbrain precerebellar neurons is independent of Slit and Robo signaling. Robo Slit Cerebellum Floor...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (22): 4125–4136.
Published: 15 November 2017
... analysis of the nascent cerebellum of transgenic Pax2-EGFP mice to address this issue. We found that cerebellar interneuronal precursors regularly show spontaneous postsynaptic currents, indicative of synaptic innervation, well before settling in the molecular layer. In keeping with the sensitivity...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (10): 1863–1875.
Published: 15 May 2017
... at E16.5, as well as numerous apoptotic CGNs at the deepest layer of the external granule layer (EGL) in the medial cerebellum of Atoh1-Cre;Rac1 flox/flox ;Rac3 −/− mice at P8. Atoh1-Cre;Rac1 flox/flox ;Rac3 −/− CGNs differentiated normally until expression of p27 kip1 and NeuN in the deep EGL at P5...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (8): 1462–1471.
Published: 15 April 2017
... in regeneration is not understood. Limited availability of specific stem cells might impair the regeneration of particular cell lineages. We studied regeneration of the adult zebrafish cerebellum, which contains two major stem and progenitor cell types: ventricular zone and neuroepithelial cells. Using...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (22): 4279–4287.
Published: 15 November 2016
..., whereas incubation for 16 h led to the near-complete loss of PCs by apoptosis. We observed synchronous cell death autonomous to the PC population and phagocytosing microglia in the cerebellum, reminiscent of developmental apoptosis in the forebrain. Thus, induction of apoptosis through targeted activation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (11): 1971–1980.
Published: 01 June 2016
... of Biologists Ltd 2016 Summary: Cerebellar deletion of Ezh2 leads to increased GABAergic interneurons, decreased Purkinje cells and blocked proliferation of granule precursor cells derived from the rhombic lip. Polycomb Ezh2 PRC2 Cerebellum Neurogenesis Purkinje cells Data...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (21): 3721–3733.
Published: 01 November 2015
.... Using light and fluorescence microscopy for the overall imaging of the specimen and fluorescence correlation spectroscopy (FCS) to determine Wnt3 dynamics, we demonstrated that Wnt3 regulates cerebellum development during embryogenesis using zebrafish wnt3 transgenics with either tissue-specific...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (3): 522–532.
Published: 01 February 2015
.... , Hertzog , P. and Busfield , S. J. ( 2004 ). Generation and characterization of neuregulin-2-deficient mice . Mol. Cell. Biol.   24 , 8221 - 8226 . 10.1128/MCB.24.18.8221-8226.2004 Buckner , R. L. ( 2013 ). The cerebellum and cognitive function: 25 years of insight from anatomy...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (14): 2791–2795.
Published: 15 July 2014
...Thomas Butts; Michalina Hanzel; Richard J. T. Wingate The cerebellum has evolved elaborate foliation in the amniote lineage as a consequence of extensive Atoh1 -mediated transit amplification in an external germinal layer (EGL) comprising granule cell precursors. To explore the evolutionary origin...
Journal Articles
Journal: Development
Development (2014) 141 (2): 389–398.
Published: 15 January 2014
... neurons in the extra-cerebellar isthmic nuclei. In the cerebellum, ectopic FGF induces proliferation while blockade reduces the length of the cerebellar rhombic lip. FGF signalling is not required for the specification of cerebellar cell types from the rhombic lip and its upregulation inhibits...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (2): 377–388.
Published: 15 January 2014
... into a coordinated cerebellum differentiation program. By contrast, in the m1b sub-domain (Pax7 + Zic1 - ) Otx2 is prevalently required for post-mitotic transition of mesencephalic GABAergic precursors. Moreover, genetic cell fate, BrdU cell labeling and Otx2 conditional inactivation experiments indicate...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (1): 166–175.
Published: 01 January 2014
... with low levels of active thyroid hormone. The postnatal defects observed in hypothyroid mouse cerebellum are recapitulated in mice heterozygous for a dominant-negative mutation of Thra , the gene encoding the ubiquitous TRα1 receptor. Using CRE/ loxP -mediated conditional expression approach, we found...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (13): 2308–2320.
Published: 01 July 2012
... ) * Present address: Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany Competing interests statement The authors declare no competing financial interests. 18 4 2012 © 2012. Neurog2 Ngn2 Purkinje cells Cell cycle Cerebellum Dendrite...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (10): 1724–1733.
Published: 15 May 2012
...Yanxin Pei; Sonja N. Brun; Shirley L. Markant; William Lento; Paul Gibson; Makoto M. Taketo; Marco Giovannini; Richard J. Gilbertson; Robert J. Wechsler-Reya The WNT pathway plays multiple roles in neural development and is crucial for establishment of the embryonic cerebellum. In addition, WNT...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (20): 4487–4497.
Published: 15 October 2011
...Baiping Wang; Wilbur Harrison; Paul A. Overbeek; Hui Zheng Correct development of the cerebellum requires coordinated sonic hedgehog (Shh) signaling from Purkinje to granule cells. How Shh expression is regulated in Purkinje cells is poorly understood. Using a novel tyrosinase minigene-tagged...
Includes: Supplementary data