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Keywords: Cerebellum
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Journal Articles
In collection:
Neural development
Journal: Development
Development (2020) 147 (19): dev190603.
Published: 9 October 2020
...Tsubasa Itoh; Miki Takeuchi; Marina Sakagami; Kazuhide Asakawa; Kenta Sumiyama; Koichi Kawakami; Takashi Shimizu; Masahiko Hibi ABSTRACT Neurons in the inferior olivary nuclei (IO neurons) send climbing fibers to Purkinje cells to elicit functions of the cerebellum. IO neurons and Purkinje cells...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2020) 147 (21): dev189019.
Published: 3 August 2020
... attributed. Summary: Genetic deficiency of Npc1 impairs postnatal development of microglia and climbing fiber synaptic pruning in the mouse cerebellum. Cerebellum CLEC7A NPC VGLUT2 Microglia Pruning Niemann–Pick disease type C (NPC) is a recessive genetic lysosomal storage...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2020) 147 (21): dev188078.
Published: 15 June 2020
... for degradation, contributing full Shh activation through an epigenetic mechanism during cerebellum development and medulloblastoma progression. RNF220 Cerebellum Sonic hedgehog EED Medulloblastoma Mouse Sonic hedgehog (Shh) signaling plays crucial roles in specifying spatial patterns and cell...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2018) 145 (5): dev158782.
Published: 8 March 2018
..., and induce sharpening, rotation and translocation of the nucleus independently of actin. Neuronal migration Cerebellum Nucleus Nesprin Microtubules Kinesin-1 Mouse During mammalian brain development, newly born neurons migrate from their birthplace in the germinal layers to their final...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2018) 145 (2): dev159400.
Published: 17 January 2018
... =4). (L) Quantification of the number of Barhl1 + cells in the auditory and trigeminal nerves in control, Dcc −/− and Wnt1:Cre; Dcc fl/fl E16 cryosections (see Table S4 ). (M) Schematic representations of precerebellar neuron migration in control and Ntn1-deficient mice. Ce, cerebellum; Hind...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2018) 145 (2): dev150375.
Published: 17 January 2018
... of Biologists Ltd 2018 Highlighted Article: The conditional ablation of Slit proteins and Robo receptors in precerebellar neurons and floor plate reveals that, in the mouse, the migration of hindbrain precerebellar neurons is independent of Slit and Robo signaling. Robo Slit Cerebellum Floor...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2017) 144 (22): 4125–4136.
Published: 15 November 2017
... analysis of the nascent cerebellum of transgenic Pax2-EGFP mice to address this issue. We found that cerebellar interneuronal precursors regularly show spontaneous postsynaptic currents, indicative of synaptic innervation, well before settling in the molecular layer. In keeping with the sensitivity...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2017) 144 (10): 1863–1875.
Published: 15 May 2017
... at E16.5, as well as numerous apoptotic CGNs at the deepest layer of the external granule layer (EGL) in the medial cerebellum of Atoh1-Cre;Rac1 flox/flox ;Rac3 −/− mice at P8. Atoh1-Cre;Rac1 flox/flox ;Rac3 −/− CGNs differentiated normally until expression of p27 kip1 and NeuN in the deep EGL at P5...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (8): 1462–1471.
Published: 15 April 2017
... in regeneration is not understood. Limited availability of specific stem cells might impair the regeneration of particular cell lineages. We studied regeneration of the adult zebrafish cerebellum, which contains two major stem and progenitor cell types: ventricular zone and neuroepithelial cells. Using...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (22): 4279–4287.
Published: 15 November 2016
..., whereas incubation for 16 h led to the near-complete loss of PCs by apoptosis. We observed synchronous cell death autonomous to the PC population and phagocytosing microglia in the cerebellum, reminiscent of developmental apoptosis in the forebrain. Thus, induction of apoptosis through targeted activation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (11): 1971–1980.
Published: 1 June 2016
... of Biologists Ltd 2016 Summary: Cerebellar deletion of Ezh2 leads to increased GABAergic interneurons, decreased Purkinje cells and blocked proliferation of granule precursor cells derived from the rhombic lip. Polycomb Ezh2 PRC2 Cerebellum Neurogenesis Purkinje cells Data...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (21): 3721–3733.
Published: 1 November 2015
.... Using light and fluorescence microscopy for the overall imaging of the specimen and fluorescence correlation spectroscopy (FCS) to determine Wnt3 dynamics, we demonstrated that Wnt3 regulates cerebellum development during embryogenesis using zebrafish wnt3 transgenics with either tissue-specific...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (3): 522–532.
Published: 1 February 2015
... of Bergmann glia - the scaffolds for granule neuron migration. Cerebellum ERBB3 Bergmann glia Mouse Beam-walk assay was performed as described previously ( Carter et al., 2001 ; Luong et al., 2011 ). On days 1-4, mice (3 months old) were subjected to testing on a round beam (12 mm in diameter...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (14): 2791–2795.
Published: 15 July 2014
...Thomas Butts; Michalina Hanzel; Richard J. T. Wingate The cerebellum has evolved elaborate foliation in the amniote lineage as a consequence of extensive Atoh1 -mediated transit amplification in an external germinal layer (EGL) comprising granule cell precursors. To explore the evolutionary origin...
Journal Articles
Journal: Development
Development (2014) 141 (2): 389–398.
Published: 15 January 2014
... neurons in the extra-cerebellar isthmic nuclei. In the cerebellum, ectopic FGF induces proliferation while blockade reduces the length of the cerebellar rhombic lip. FGF signalling is not required for the specification of cerebellar cell types from the rhombic lip and its upregulation inhibits...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (2): 377–388.
Published: 15 January 2014
... into a coordinated cerebellum differentiation program. By contrast, in the m1b sub-domain (Pax7 + Zic1 - ) Otx2 is prevalently required for post-mitotic transition of mesencephalic GABAergic precursors. Moreover, genetic cell fate, BrdU cell labeling and Otx2 conditional inactivation experiments indicate...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (1): 166–175.
Published: 1 January 2014
... with low levels of active thyroid hormone. The postnatal defects observed in hypothyroid mouse cerebellum are recapitulated in mice heterozygous for a dominant-negative mutation of Thra , the gene encoding the ubiquitous TRα1 receptor. Using CRE/ loxP -mediated conditional expression approach, we found...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (13): 2308–2320.
Published: 1 July 2012
... ). EdU incorporation was revealed using the Click-iT EdU Imaging Kit (Invitrogen). Cell-cycle progression in the cerebellum was analyzed as described ( Takahashi et al., 1993 ). Cell-cycle phases in Neurog2 CreER/+ and Neurog2 CreER/CreER were compared using a t -test for paired samples...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (10): 1724–1733.
Published: 15 May 2012
...Yanxin Pei; Sonja N. Brun; Shirley L. Markant; William Lento; Paul Gibson; Makoto M. Taketo; Marco Giovannini; Richard J. Gilbertson; Robert J. Wechsler-Reya The WNT pathway plays multiple roles in neural development and is crucial for establishment of the embryonic cerebellum. In addition, WNT...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (20): 4487–4497.
Published: 15 October 2011
...Baiping Wang; Wilbur Harrison; Paul A. Overbeek; Hui Zheng Correct development of the cerebellum requires coordinated sonic hedgehog (Shh) signaling from Purkinje to granule cells. How Shh expression is regulated in Purkinje cells is poorly understood. Using a novel tyrosinase minigene-tagged...
Includes: Supplementary data