...Jennifer K. Ocasio; Rolf Dale P. Bates; Carolyn D. Rapp; Timothy R. Gershon ABSTRACT Cerebellar development requires regulated proliferation of cerebellar granule neuron progenitors (CGNPs). Inadequate CGNP proliferation causes cerebellar hypoplasia whereas excessive CGNP proliferation can cause...

...), raising questions regarding its role as a regulator of neural progenitor cell cycle progression in cerebellar development. To characterize in vivo the function of ZFP423 in neurogenesis, we analyzed allelic murine mutants in which distinct functional domains are deleted. One deletion impairs mitotic...

.... , et al. ( 2013 ). Distinct roles for fibroblast growth factor signaling in cerebellar development and medulloblastoma . Oncogene   32 , 4181 - 4188 . 10.1038/onc.2012.440 Espinosa , J. S. and Luo , L. ( 2008 ). Timing neurogenesis and differentiation: insights from quantitative...

... to their mature location in the inner granule layer. In this study, we examined the expression of D type cyclins in GNPs during cerebellar development and showed that GNPs in early development expressed only cyclin D1, whereas later GNPs expressed both cyclins D1 and D2. Coinciding with the period of cyclin D1...

... development. * Author for correspondence (e-mail: xliu@mednet.ucla.edu ) 5 5 2005 ©2005. 2005 PTEN Bergmann glia Cerebellar development Mouse Precise neuronal functions require highly ordered cell proliferation,differentiation, migration and synaptic specificity...

... of the Purkinje cells occurs within the ventricular zone during the early phases of cerebellar development,Purkinje cell precursors migrate to form the first cell layer and thereby set up the framework for the cerebellar cortex. Concomitantly, granule cell precursors appear in an area of the neuroepithelium...

... in truncation of the Rb protein that is functionally equivalent to a null allele. Both En2cre; Rb LoxP/+ and En2cre;Rb LoxP/LoxP mice were healthy and fertile and showed no indications of cerebellar malfunction. We examined the cerebella of these mice at time points pivotal for cerebellar development...

... that precise spatio-temporal regulation of TAG-1 and F3/contactin expression is critical for normal cerebellar morphogenesis. † Authors for correspondence (e-mail: G.Gennarini@tno.it and A.J.Furley@Sheffield.ac.uk ) 3 10 2002 © 2003. 2003 Cerebellar development Neurite growth...

... disruption of two negative regulators of Rac, Abr and Bcr , in mice leads to specific abnormalities in postnatal cerebellar development. Mutants exhibit granule cell ectopia concomitant with foliation defects. We provide evidence that this phenotype is causally related to functional and structural...

... for the appropriate balance of transcriptional activators and repressors during postnatal cerebellar development. To investigate the influence of the rev-erbA α deletion on the expression of the overlapping TR α gene, we hybridized northern blots with probes specific for TR α isoforms ( Fig. 1B ). A strand...