... of cell specification, differentiation and organogenesis. This progenitor cell gives rise to a clone of 20 cells comprising the intestine, which are arranged in nine rings (int1-9) spanning the length of the animal ( Fig. S1A ). Endoderm development is driven by three pairs of duplicated genes encoding...

... mutants ( Fig. S16A ). This indicates that Hcrt cells are never generated and/or specified in the mutants. Because Lhx9 is one of the few known TFs involved in Hcrt cell specification, we examined Lhx9 expression in the temporal UMAP space. This revealed a specific Hes5−, Sox2+, Lhx9+ progenitor...

... - original draft: A.P.S., K.L., J.W.; Writing - review & editing: A.P.S., K.L., J.W.; Visualization: A.P.S., K.L.; Supervision: J.W.; Project administration: J.W.; Funding acquisition: J.W. Notch Atoh7 Retinal progenitors Post-embryonic growth Cell specification Medaka The central...

... et al., 2007 ; Jacob et al., 1999 ; Mullen and Behringer, 2014 ). In addition, WD and MD form in close proximity, suggesting the possibility of reciprocal interactions. Müllerian duct Cell specification Invagination Apical constriction Wolffian duct Summary: In the developing...

..., suggesting that they contribute to establishing regional identity. Cell specification Neural development Neural stem cells MicroRNA MicroRNAs (miRNAs) are small noncoding RNAs that mediate post-transcriptional regulation of gene expression ( Bartel, 2004 ). A single miRNA can have up...

... for cell specification in Arabidopsis embryogenesis . Dev. Cell   10 , 265 - 270 . 10.1016/j.devcel.2005.12.001 Wendrich , J. R. and Weijers , D. ( 2013 ). The Arabidopsis embryo as a miniature morphogenesis model . New Phytol.   199 , 14 - 25 . 10.1111/nph.12267 Williams...

... that a temporal factor may play dual roles, acting at two different stages during the development of one neural lineage. Temporal genes COUP-TFI/II Cell specification Lineage progression Drosophila Neural progenitor cells, in both vertebrates and invertebrates, go through temporal...

...Olga Kirioukhova; Amal J. Johnston; Daniela Kleen; Christina Kägi; Ramamurthy Baskar; James M. Moore; Helmut Bäumlein; Rita Groß-Hardt; Ueli Grossniklaus In plants, gametes, along with accessory cells, are formed by the haploid gametophytes through a series of mitotic divisions, cell specification...

... and Endocrinology, Juntendo University,2-1-1 Hongo, Bunkyo-Ku, Tokyo 113-8421, Japan 30 8 2006 © 2006. 2006 Retinal development Basic helix-loop-helix Amacrine cell Horizontal cell Ganglion cell Lineage tracing Ptf1a Foxn4 Progenitor Cell specification The vertebrate neural...

... Neurohypophysis Zebrafish Pia Cell survival Cell specification Apoptosis The hypothalamic-hypophyseal axis constitutes a functional link between the nervous and the endocrine system. As a key regulator of hormone secretion, the hypophysis, also called pituitary gland, controls basic vital...

... Adenohypophysis Neurohypophysis Zebrafish Lia Cell survival Cell specification Apoptosis Sonic Hedgehog © 2004. 2004 21 4 2004 † Present address: University of Sheffield, Department of Biomedical Science,Firth Court, Western Bank, Sheffield S10 2TN, UK * Present address...

... 2003 © 2003. 2003 Transcriptional regulation Cell specification Zinc finger proteins TEF RFX factors Polycystins Because of its simple nervous system with invariant cell lineage and position, C. elegans provides an excellent model to study how diverse neuronal subtypes...

... for correspondence (e-mail: scamper@umich.edu ) 23 10 2001 © 2002. 2002 Pitx2 Pitx1 Gata2 Allelic series Gene dosage Cell specification Mouse The mammalian Pitx gene family consists of three bicoid-related homeobox genes, each with an important role in the development...

... in plants. *Author for correspondence (e-mail: Liam.Dolan@bbsrc.ac.uk ) 8 10 2001 © 2002. 2002 Epidermal pattern Radial pattern Cell specification Katanin ectopic root hair3 Arabidopsis thaliana Multicellular organisms are composed of different specialised cells...

... formation of the apical meristems and shortly after the cellular anatomy of the protoderm and outer ground tissue layer is established. Thus, epidermal cell specification in the Arabidopsis seedling relies on the embryonic establishment of a patterning mechanism that is perpetuated postembryonically...

... Progenitor cells Cell specification Cell signalling Glia Neuron Mouse One of most important aspects of the cellular organization of the nervous system is the presence of a large number of differentiated cell types that can mediate distinct functions. During development, differentiated cell types...

... developmental gene function may arise solely by the modification of cis -regulatory sequences. * Author for correspondence (e-mail: schiefel@umich.edu ) 05 04 2001 12 02 2001 © 2001 by Company of Biologists 2001 MYB genes Cell specification Epidermis Gene evolution...

... and trn2 roots indicating that TRN1 and TRN2 are required for the maintenance of the radial pattern of cell specification in the root. The death of these ectopic lateral root cap cells in the elongation zone (where lateral root cap cells normally die) results in the development of gaps in the epidermis...

... in this paper represent the first demonstration in the sea urchin of the possible involvement of a homeobox gene in cell specification along an embryonic axis. The O-A axis is set up by the two-cell stage ( Cameron et al., 1989 ) but, as shown by the effects of nickel treatment, becomes committed by the onset...

... lineage itself is suppressed by the C lineage. 28 03 1995 © 1995 by Company of Biologists 1995 cell specification autonomy nonautonomy induction evolution Caenorhabditis Two basic modes of cell determination are proposed for the specification of cell fates during...