... molecular, cellular, organ-level and organismal mechanisms. Sex difference Cell death Cell proliferation Stem cell Organ homeostasis Cell signaling Canadian Institutes for Health Research PJT-153072 GS4-171365 Natural Sciences and Engineering Research Council of Canada...

... and elevate yields in indica rice varieties ( Ashikari et al., 2005 ; Yeh et al., 2015 ). Cell signaling Cytokinin Plant development Plant hormones Summary: Disrupting a subset of histidine kinase (HK) genes in Oryza sativa reveals that HK5 and HK6 act as cytokinin receptors...

... that genetically interacts with Notch pathway components, is a component of the Notch-Su(H) activation complex and positively regulates Notch signaling. Cell signaling Notch Activation complex Enhancer of Split complex Chromo-domain Hat-trick Drosophila Notch signaling is an evolutionarily...

... Epigenetics Cell signaling Differentiation Skeletal muscle owes its considerable regenerative capacity to a population of resident muscle stem cells called satellite cells ( Lepper et al., 2011 ; McCarthy et al., 2011 ; Murphy et al., 2011 ; Sambasivan et al., 2011 ). These cells, which...

... Cell signaling Two-component signaling ...

... collection of 165 Drosophila miRNA transgenes and find that a majority induced specific developmental defects, including phenocopies of mutants in myriad cell-signaling and patterning genes. Such connections allowed us to validate several likely targets for miRNA-induced phenotypes. Importantly, few...

...-dependent cell-cell signaling. These findings indicate that Crb acts as a cell-contact-dependent receptor that regulates growth by modulating Hippo pathway activity. The Drosophila Crumbs (Crb) protein was recently added to the Hippo pathway as a potential new receptor ( Chen et al., 2010 ; Ling et...

... and Albertson, 2008 ; Oates et al., 2009 ). Although these results specifically address the relationship of SHH-signaling strength to midfacial growth and shape, this approach can be applied to other related cell-signaling pathways (e.g. BMP, WNT, FGF, etc.) and anatomical structures (e.g. the autopod). Future...

...@ibt.tmc.edu ) 12 9 2008 © 2008. 2008 Receptor tyrosine kinase Cell signaling Heart development Second heart field Mouse model Congenital heart disease (CHD) represents the most common birth defect in humans, affecting nearly 1% of newborns. Since more than 30% of CHD patients...

... 2008. 2008 Drosophila Cell signaling Feedback modulation Transcriptional repression A limited number of intercellular signaling pathways are used reiteratively in different contexts to control the development of metazoans. An unanswered question in the study of organism development...

... and the dynamic character of Br expression, we revisited the effect of Dpp on Br. † Author for correspondence (e-mail: stas@princeton.edu ) Cell signaling Epithelial patterning Feedforward control Pattern formation Drosophila Pattern formation in development relies on combinatorial...

... Fgf8 Isthmus Cell signaling Ras ERK Chick Classical transplantation studies in chick embryos first revealed that the mes/metencephalic boundary (MHB, also referred to as the isthmus) has an organizing activity for the mesencephalon and the metencephalon (reviewed by Joyner et al., 2000...

... robusta Gut formation Cell signaling The gene hedgehog ( hh ) was originally identified in Drosophila as a segment polarity gene( Heemskerk and DiNardo, 1994 ; Ingham et al., 1991 ). Subsequently, hh -class genes have been found in many organisms including chordates [ Amphioxus , zebrafish...

.... 2002 Pax Transgenesis no isthmus Fgf8 engrailed Zebrafish Danio rerio Cell signaling CNS Midbrain Hindbrain Isthmus Organizer Pattern formation During pattern formation in vertebrate neural development regional gene expression is integrated and co-ordinated...

... between FGF8 and FGF10 is essential for limb induction. Development 125 , 753 -765. †Author for correspondence (e-mail: saverio.bellusci@curie.fr ) 5 10 2001 © 2002. 2002 Fgf10 Fgfr2b Lef1 Mammary placode development Mouse Cell signaling Mammary gland...

..., Y., Yang, X. and Chia, W. ( 2000 ). Analysis of partner of inscuteable, a novel player of Drosophila asymmetric divisions, reveals two distinct steps in inscuteable apical localization. Cell 100 , 399 -409. Neurogenesis Slit Roundabout Cell signaling Ganglion mother cells Asymmetric...