...Yichi Xu; Yunsheng Cheng; Allison T. Chen; Zhirong Bao ABSTRACT The formation of sequential rosettes is a type of collective cell behavior recently discovered in the Caenorhabditis elegans embryo that mediates directional cell migration through sequential formation and resolution of multicellular...

... hematopoiesis in zebrafish. Hematopoietic niche Stromal cells Cell migration Protocadherin Somite Zebrafish Institut Pasteur http://dx.doi.org/10.13039/501100003762 Centre National de la Recherche Scientifique http://dx.doi.org/10.13039/501100004794 Fondation pour...

... Douarin et al., 2004 ; Noden and Trainor, 2005 ). Mouse genetics Neural tube closure Epithelial-to-mesenchymal transition Neural tube explants Cell delamination Cell migration Summary: A previously unreported function for Twist1 in neural tube closure and epithelial-to-mesenchymal...

...Naoya Yamaguchi; Holger Knaut ABSTRACT Cell-extracellular matrix interactions have been studied extensively using cells cultured in vitro . These studies indicate that focal adhesion (FA)-based cell-extracellular matrix interactions are essential for cell anchoring and cell migration. Whether FAs...

..., leading to increased speed of migration. Moreover, overactivation of Rac1, due to Piezo1 inhibition, counteracts cell migration inhibitory signals by Semaphorin 3A and Semaphorin 3F, generating aberrant neural crest invasion in vivo . Thus, we find that, for directional migration in vivo , neural crest...

...Jessica Stock; Andrea Pauli ABSTRACT Self-organization is a key feature of many biological and developmental processes, including cell migration. Although cell migration has traditionally been viewed as a biological response to extrinsic signals, advances within the past two decades have...

... cell movement at the leading edge mesendoderm surface allows this tissue to move by being pulled forward by cells at its front end. Xenopus X-ray tomography Gastrulation Cell migration Surface tension Mass cell migration positions organ rudiments during development. In the Xenopus...

.... Subtracting Eqn 7 from Eqn 6 gives (Eqn 8) Highlighted Article: The final position of a migrating neuroblast is rather invariant in C. elegans . However, consistent with its migration arrest being temporally regulated, its final position is sensitive to body size. Cell migration...

... in the mouse. This collective cell migration is preceded by a columnar-to-squamous transition in visceral endoderm cells that depends on MLL4. Furthermore, Mll4 mutants display incompletely penetrant, sex-distorted, embryonic haploinsufficiency and adult heterozygous mutants show aspects of Kabuki syndrome...

...Abhinava K. Mishra; Joseph P. Campanale; James A. Mondo; Denise J. Montell ABSTRACT Collective cell migration is the coordinated movement of a physically connected group of cells and is a prominent driver of development and metastasis. Interactions between cells within migrating collectives...

... the importance of cholesterol modification in the processing and long-distance transmission of the Hh ligand, we have analyzed the involvement of the Niemann-Pick disease type C-1a (NPC1a) protein, a cholesterol transporter, in germ cell migration and Hedgehog signaling. We show that mesoderm-specific...

... overlying the extra-embryonic ectoderm shows coherent cell growth in a proximal-anterior to distal-posterior direction. We also observed that directional cell migration is coupled with cell elongation in the anterior region. Our observations suggest that the behaviors of visceral endoderm cells vary between...

..., and a constitutively active form of Src efficiently rescues the Gα13 morphant phenotype in NC cells. We propose that Ric-8A-mediated Gα13 signalling is required for proper cranial NC cell migration by regulating focal adhesion dynamics and protrusion formation. * Authors for correspondence ( matorrejon@udec.cl...

... and the persistence index of CE ( Fig. 7 A-E). These data indicate that mmp14a/mmp14b -depleted endodermal cells migrate less efficiently than their wild-type counterparts. Furthermore, monitoring the actin dynamics of Tg(sox17:GFP-UTRN) showed that similar to gpc4 mutant embryos, actin-rich protrusions...

... and to specifically decipher the mechanisms controlling collective cell migration. Here, we identify the Drosophila Insulin/Insulin-like growth factor signalling (IIS) pathway as a key regulator in controlling actin dynamics in border cells, independently of its function in growth control. Loss of IIS activity blocks...

... that Cdc42 is required for endothelial tip cell selection, directed cell migration and filopodia formation, but dispensable for cell proliferation or apoptosis. Although the loss of Cdc42 seems generally compatible with apical-basal polarization and lumen formation in retinal blood vessels, it leads...

... in increased proliferation under flow (orbital). Data are mean±s.d. ns, non-significant; *P≤0.05; **P≤0.01; ***P≤0.001. EC, endothelial cell; FOV, field of view. Scale bars: 20 µm. Fig. 4. Shear stress-guided cell migration is undirected in the absence of SMAD4 . (A) Still micrographs from time...

...James B. Skeath; Beth A. Wilson; Selena E. Romero; Mark J. Snee; Yi Zhu; Haluk Lacin The extracellular matrix (ECM) regulates cell migration and sculpts organ shape. AdamTS proteins are extracellular metalloproteases known to modify ECM proteins and promote cell migration, but demonstrated roles...

... that, despite the depletion of MyoII function, tip cell migration and stalk cell intercalation (SCI) proceed at a normal rate. This confirms a model in which DB elongation and SCI in the trachea occur as a consequence of tip cell migration, which produces the necessary forces for the branching process...

..., high COUP-TFI expression levels downregulate Cxcr4 expression, whereas increased Cxcr4 expression in wild-type hippocampal cells affects cell migration. Finally, loss of COUP-TFI in postmitotic cells leads to only minor and transient abnormalities, and to normal Cxcr4 expression. Together, our results...