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Keywords: Cell fate
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Journal Articles
Journal: Development
Development (2022) 149 (6): dev200375.
Published: 25 March 2022
... precursor pool. Sustained Wt1 expression in cardiomyocytes can change their cell fate into epicardial-like cells. wt1a wt1b Heart development Cardiomyocyte Epicardium Zebrafish Cell fate Schweizerischer Nationalfonds zur Förderung der wissenschaftlichen Forschung http...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (2): dev199853.
Published: 28 January 2022
... into functional insulin expressing cells. This rapid cell conversion may hold the key to the extraordinary ability of zebrafish to recover from diabetes even after its β-cells are completely destroyed. Beta-cell Insulin Pancreas Regeneration Single cell Zebrafish Gamma-cell Cell fate Cell plasticity...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (2): dev199634.
Published: 24 January 2022
... results from M cells prematurely adopting a head epidermis fate. This switch in fate normally takes place during pupal development after the eye has been patterned. Our results suggest that the timing of cell fate decisions is essential for correct eye development. * Author for correspondence...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (2): dev194407.
Published: 24 January 2022
... of the Wnt/β-catenin pathway, which is required for melanocyte development, induces activation of Mitf-M, in turn repressing FoxD3 expression. In conclusion, β-catenin overexpression promotes SCP cell fate decisions towards the melanocyte lineage. 501mel and SK28 human melanoma cell lines were grown...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (2): dev199484.
Published: 17 January 2022
... by The Company of Biologists Ltd 2022 Summary: The Foxn3 transcription factor and microRNA miR-216b can modulate formation of amacrine cells in the developing mouse retina, suggesting a new regulatory pathway for retinal interneuron formation. Cell fate microRNA Retina Neurogenesis...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (24): dev199779.
Published: 22 December 2021
...Megan K. Rommelfanger; Adam L. MacLean ABSTRACT Cells do not make fate decisions independently. Arguably, every cell-fate decision occurs in response to environmental signals. In many cases, cell-cell communication alters the dynamics of the internal gene regulatory network of a cell to initiate...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (11): dev199609.
Published: 12 June 2021
...Lluc Mosteiro; Hanaa Hariri; Jelle van den Ameele ABSTRACT The intimate relationships between cell fate and metabolism have long been recognized, but a mechanistic understanding of how metabolic pathways are dynamically regulated during development and disease, how they interact with signalling...
Journal Articles
Journal: Development
Development (2021) 148 (4): dev196030.
Published: 15 February 2021
...Natalie J. Milmoe; Abigail S. Tucker ABSTRACT Within the developing head, tissues undergo cell-fate transitions to shape the forming structures. This starts with the neural crest, which undergoes epithelial-to-mesenchymal transition (EMT) to form, amongst other tissues, many of the skeletal tissues...
Journal Articles
Journal: Development
Development (2020) 147 (18): dev188730.
Published: 28 September 2020
... the rod-promoting factor Nrl to control the timing of cone genesis in the mouse retina. Cell fate Mouse Photoreceptors Retina Temporal patterning Transcription The generation of neuronal diversity is crucial to building a functional nervous system. Classical studies have shown...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (15): dev186965.
Published: 14 August 2020
... for endoderm fate specification. These results illustrate commonalities as well as differences in the action of Nodal during ascidian and vertebrate gastrulation. Nodal Ephrin Gastrulation Morphogenesis Cell fate Highlighted Article: This study identifies a signalling relay regulating cell...
Includes: Supplementary data
Journal Articles
In collection:
Human development
Journal: Development
Development (2020) 147 (14): dev190629.
Published: 17 July 2020
...Marta N. Shahbazi ABSTRACT Gene regulatory networks and tissue morphogenetic events drive the emergence of shape and function: the pillars of embryo development. Although model systems offer a window into the molecular biology of cell fate and tissue shape, mechanistic studies of our own...
Journal Articles
Journal: Development
Development (2020) 147 (12): dev175059.
Published: 19 June 2020
... in development and evolution, the LPM remains challenging to study and to delineate, owing to its lineage complexity and lack of a concise genetic definition. Here, we outline the processes that govern LPM specification, organization, its cell fates and the inferred evolutionary trajectories of LPM-derived...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (11): dev175760.
Published: 4 June 2020
... are required for the polarized and directional secretion of the epidermal growth factor during vulval development in C. elegans . C. elegans Epidermal growth factor Polarity Cell fate Intercellular communication relies on the spatially and temporally controlled release of signaling...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (5): dev181297.
Published: 2 March 2020
... behaviours and ensure robust morphogenesis and patterning during development. Luminal pressure Luminogenesis Signalling Cell fate Tissue patterning Tissue mechanics In many epithelial tissues, cells secrete intercellular fluid that leads to the de novo formation of the lumen (see...
Journal Articles
Journal: Development
Development (2019) 146 (20): dev180224.
Published: 23 October 2019
.... Highlighted Article: A combination of lineage tracing and whole-mount imaging uncovers how the multipotency of basal stem cells is regulated during postnatal prostate development in mouse. Stem cells Prostate development Basal multipotency Cell fate Lineage tracing Mouse The prostate...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2019) 146 (20): dev180430.
Published: 18 October 2019
... in mouse Müllerian duct mesenchyme cells caused them to adopt the myofibroblast cell fate, resulting in profound reproductive tract developmental defects and sterility. Myofibroblast differentiation was attributed to increased YAP and TAZ expression (but not to altered WNT signaling), leading to the direct...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (18): dev178996.
Published: 19 September 2019
... interests. © 2019. Published by The Company of Biologists Ltd 2019 Summary: This Meeting Review discusses how recent technological advances have impacted the study of cell types and how this might change our view of cell type identity and evolution. Cell fate Computational analysis...
Journal Articles
Journal: Development
Development (2019) 146 (18): dev167106.
Published: 16 September 2019
.... the Wnt, Hedgehog and TGFβ pathways), Hippo signalling is a ‘jack of all trades’ that is reiteratively used to mediate a range of cellular decision-making processes from proliferation, death and morphogenesis to cell fate determination. Here, and in the accompanying poster, we briefly outline the core...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (16): dev176586.
Published: 21 August 2019
... ). The roles of intrinsic and extrinsic cues and bHLH genes in the determination of retinal cell fates . Curr. Opin. Neurobiol.   9 , 37 - 46 . 10.1016/s0959-4388(99)80005-1 Donovan , S. L. , Schweers , B. , Martins , R. , Johnson , D. and Dyer , M. A. ( 2006 ). Compensation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (7): dev170498.
Published: 1 April 2019
... early mesoderm cell fate decisions. We found that Cdx2 occupies a number of transcription factor loci during embryogenesis, including key regulators of both cardiac and blood development, and that Cdx function is required for normal expression of the cardiogenic transcription factors Nkx2-5 and Tbx5...
Includes: Supplementary data