... shelves and must be removed to allow mesenchymal confluence. Abundant apoptosis and cell extrusion support their importance in MES removal. However, genetically disrupting the intrinsic apoptotic regulators BAX and BAK within the MES results in complete loss of cell death and cell extrusion...

...Xianlong Ai; Dan Wang; Junzheng Zhang; Jie Shen ABSTRACT Cell extrusion is a crucial regulator of epithelial tissue development and homeostasis. Epithelial cells undergoing apoptosis, bearing pathological mutations or possessing developmental defects are actively extruded toward elimination...

... ( Fig. 2 D,E). The speed of LEC area constriction at the late stage upon Myosin II inhibition was also comparable to controls at the late stage ( Fig. 3 I-L), suggesting that Myosin II does not provide a major driving force for cell extrusion and instead acts to promote cell elimination at a more...

... a developmental switch in the cell extrusion mechanism that correlates with changes in tissue mechanical properties. * Author for correspondence ( christian.dahmann@tu-dresden.de ) Competing interests The authors declare no competing or financial interests. 16 4 2019 28 1 2020 ©...

... PE cells to extrude apically. We provide evidence that cell extrusion, which has been described in the elimination of unfit cells from epithelia and the emergence of hematopoietic stem cells, is also a mechanism for PE cells to exit an organized mesothelium and fulfil their developmental fate to form...