... production in invertebrates, where the final topology is typically invariant within each species, we devised a mathematical model for generating cell networks, in which each node is an oscillator and, after a full cycle, the node produces a daughter to which it remains connected. These cell cycle...

... of the mitotic spindle in vitro in human cells and in vivo in Xenopus . Investigation of CHD2 provides evidence that mutations present in individuals with ASD cause a range of microtubule-related phenotypes, including disrupted localization of the protein at mitotic spindles, cell cycle stalling, DNA damage...

... at the shoot apex and root tip. As TSO1 and MYB3R1 are homologous to components of an animal cell cycle regulatory complex, DREAM, Arabidopsis mutants of TSO1 and MYB3R1 provide valuable tools for investigations into the link between cell cycle regulation and stem cell maintenance in plants. In this study...

... of the ventral telencephalic marker COUPTFII, with increased variability in these properties. Cell cycle analysis revealed an increase in total cell cycle length caused primarily by an elongated G1 phase, the duration of which also varied more than normal. At later stages, deletion organoids increased their NEUN...

..., revealed that in addition to directly binding cell cycle-promoting genes, including Myc and stg , Psi was enriched on genes implicated in developmental signalling. Moreover, RNA sequencing (RNA-seq) detected both up- and downregulation of direct targets in Psi-depleted wings, implying Psi not only...

... by a ‘grape’ karyotype, owing to the defects in chromosome alignment. Abnormal alternatively spliced genes related to chromosome segregation, the microtubule cytoskeleton, cell cycle kinases and DNA damage were present in the dhx38 mutants. Subsequently, EMPs and HSPCs in dhx38 mutants underwent P53-dependent...

...Timothy J. Duerr; Eun Kyung Jeon; Kaylee M. Wells; Antonio Villanueva; Ashley W. Seifert; Catherine D. McCusker; James R. Monaghan ABSTRACT Regulation of cell cycle progression is essential for cell proliferation during regeneration following injury. After appendage amputation, the axolotl...

... daughters where it transactivates Notch in neuroblasts. Over time, in response to intrinsic temporal cues and increasing numbers of Delta-expressing daughters, neuroblast Notch activity increases, leading to cell cycle exit and consequently, attenuation of Notch pathway activity. Quiescent neuroblasts have...

... unseen signaling dynamics in single pluripotent cells, which alternate between oscillatory and non-oscillatory ERK activity. ERK dynamics change with ligand concentration, cell cycle and differentiation state. FGF/ERK signaling Cell cycle Mouse embryonic stem cells Oscillations Signal...

... spliceosome in the developing mouse pallium, causing microcephaly. There, cell cycle defects and p53-mediated apoptosis in response to DNA damage resulted in loss of radial glial cells (RGCs), underpinning microcephaly. Here, we ablated Trp53 to block cell death in Rnu11 cKO mice. We report that Trp53...

... suppression, and EPF2 appears to be the signal coordinating the trade-off between division propensity of meristemoids and their sister SLGCs. Polarity domains can act as hubs to coordinate multiple cellular behaviors across the cell cycle. Our understanding of how these potentially independent...

... follicular development. However, the mechanisms involved in controlling GC cell cycle are not fully understood. Here, by performing gene expression profiling in the domestic pig ( Sus scrofa ), we showed that cell cycle arrest at G0/G1 phase is highly correlated with pathways associated with hypoxic stress...

...Susanna E. Brantley; Stefano Di Talia ABSTRACT Understanding the mechanisms of embryonic cell cycles is a central goal of developmental biology, as the regulation of the cell cycle must be closely coordinated with other events during early embryogenesis. Quantitative imaging approaches have...

... Summary: This Review synthesizes current understanding of Hedgehog signal transduction, ligand secretion and transport, and cilia dynamics to explore the temporal and spatial constraints imposed by the primary cilium on Hedgehog signaling in vivo . Hedgehog Cell cycle Cilia Signaling...

.... However, the functional mechanism of Arid1a in the fate commitment of mesenchymal stem cells (MSCs) and their progeny is not clear. Using the continuously growing adult mouse incisor model, we show that Arid1a maintains tissue homeostasis through limiting proliferation, promoting cell cycle exit...

...Noelia Urbán; Tom H. Cheung ABSTRACT Quiescence is a cellular state in which a cell remains out of the cell cycle but retains the capacity to divide. The unique ability of adult stem cells to maintain quiescence is crucial for life-long tissue homeostasis and regenerative capacity. Quiescence has...

... of the cell cycle. These combined effects partner to establish and sustain a pool of rapidly proliferating radial glial progenitors in vitro . We also show that, in conditions of variable proliferation dynamics, the branching process tool outperforms other commonly used methods based on thymidine analogs...

..., and thereafter balancing SSC renewal versus terminal differentiation. Here, we report that precise regulation of the cell cycle is crucial for this balance. Whereas cyclin-dependent kinase 2 ( Cdk2 ) is not necessary for mouse viability or gametogenesis stages prior to meiotic prophase I, mice bearing...

... proliferation is drastically reduced, but resumes when food becomes available. Here, we investigate how neural progenitors halt cell division in response to nutrient restriction and subsequently re-enter the cell cycle upon feeding. We demonstrate that nutrient restriction causes neural progenitors to arrest...

... and sustained cell cycle progression in mammalian neuronal precursors . Mol. Cell. Biol.   20 , 9055 - 9067 . 10.1128/MCB.20.23.9055-9067.2000 Kenney , A. M. , Cole , M. D. and Rowitch , D. H. ( 2003 ). Nmyc upregulation by sonic hedgehog signaling promotes proliferation in developing...