...Patricia Murphy; Md Humayun Kabir; Tarini Srivastava; Michele E. Mason; Chitra U. Dewi; Seakcheng Lim; Andrian Yang; Djordje Djordjevic; Murray C. Killingsworth; Joshua W. K. Ho; David G. Harman; Michael D. O'Connor ABSTRACT Cataracts cause vision loss and blindness by impairing the ability...

... in lens morphogenesis and denucleation of lens fibers. Lens Terminal differentiation Smarca4 Brg1 Smarca5 Snf2h Denucleation Cataract ATP-dependent chromatin remodeling is required for transcription, DNA replication, DNA repair and genetic recombination ( de la Serna et al., 2006...

... basis of inductive tissue interactions and for studying cataract, the leading cause of blindness. The formation of tightly controlled cell-cell adhesions and cell-matrix junctions between lens epithelial (LE) cells, between lens fiber (LF) cells, and between these two cell populations enables...

...Katsutoshi Goishi; Akio Shimizu; Gabriel Najarro; Sumiko Watanabe; Rick Rogers; Leonard I. Zon; Michael Klagsbrun Cataracts, the loss of lens transparency, are the leading cause of human blindness. The zebrafish embryo, with its transparency and relatively large eyes, is an excellent model...

...Chun-hong Xia; Haiquan Liu; Debra Cheung; Catherine Cheng; Eddie Wang; Xin Du; Bruce Beutler; Woo-Kuen Lo; Xiaohua Gong Different mutations of α3 connexin (Cx46 or Gja8 ) andα8 connexin (Cx50 or Gja8 ), subunits of lens gap junction channels, cause a variety of cataracts via unknown mechanisms. We...

... (Cx46) and α1 (Cx43), and which are encoded by three different genes. In a previous study, we reported that, with a disruption of Gja3 (α3 connexin), mice developed nuclear cataracts with a normal sized lens. We show that Gja8tm1 (α8–/–) mice develop microphthalmia with small lenses and nuclear...

... retinoic acid-binding protein I in development by ectopically expressing it in the mouse lens, under the control of the A-crystallin promoter. We show that this ectopic expression interferes with the development of the lens and with the differentiation of the secondary lens fiber cells, causing cataract...