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Development (2021) 148 (14): dev199401.
Published: 26 July 2021
... muscle cells, termed cardiomyocytes, are one such example of polyploid cells. Terminally differentiated cardiomyocytes are bi- or multi-nucleated, or have polyploid nuclei. Recent mechanistic studies of polyploid cardiomyocytes indicate that they can limit cellular proliferation and, hence, heart...
Junji Itou, Isao Oishi, Hiroko Kawakami, Tiffany J. Glass, Jenna Richter, Austin Johnson, Troy C. Lund, Yasuhiko Kawakami
Development (2012) 139 (22): 4133–4142.
Published: 15 November 2012
...Junji Itou; Isao Oishi; Hiroko Kawakami; Tiffany J. Glass; Jenna Richter; Austin Johnson; Troy C. Lund; Yasuhiko Kawakami Adult zebrafish possess a significant ability to regenerate injured heart tissue through proliferation of pre-existing cardiomyocytes, which contrasts with the inability...
Includes: Supplementary data