... muscle cells, termed cardiomyocytes, are one such example of polyploid cells. Terminally differentiated cardiomyocytes are bi- or multi-nucleated, or have polyploid nuclei. Recent mechanistic studies of polyploid cardiomyocytes indicate that they can limit cellular proliferation and, hence, heart...

...Junji Itou; Isao Oishi; Hiroko Kawakami; Tiffany J. Glass; Jenna Richter; Austin Johnson; Troy C. Lund; Yasuhiko Kawakami Adult zebrafish possess a significant ability to regenerate injured heart tissue through proliferation of pre-existing cardiomyocytes, which contrasts with the inability...