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Keywords: Cardiomyocyte
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Journal Articles
Journal: Development
Development (2022) 149 (6): dev200375.
Published: 25 March 2022
.... Proepicardial cells are subsequently transferred to the myocardial surface and form the epicardium, covering the myocardium. We found that while wt1a and wt1b expression is maintained in proepicardial cells, it is downregulated in pericardial cells that contribute cardiomyocytes to the developing heart...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (19): dev178632.
Published: 9 October 2019
...Raz Ben-Yair; Vincent L. Butty; Michele Busby; Yutong Qiu; Stuart S. Levine; Alon Goren; Laurie A. Boyer; C. Geoffrey Burns; Caroline E. Burns ABSTRACT Deciphering the genetic and epigenetic regulation of cardiomyocyte proliferation in organisms that are capable of robust cardiac renewal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (4): 580–589.
Published: 15 February 2017
...Qi Xiao; Guoxin Zhang; Huijuan Wang; Lai Chen; Shuangshuang Lu; Dejing Pan; Geng Liu; Zhongzhou Yang In the field of heart regeneration, the proliferative potential of cardiomyocytes in postnatal mice is under intense investigation. However, solely relying on immunostaining of proliferation markers...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (10): 1688–1696.
Published: 15 May 2016
...Matthew J. Foglia; Jingli Cao; Valerie A. Tornini; Kenneth D. Poss ABSTRACT The orchestrated division of cardiomyocytes assembles heart chambers of distinct morphology. To understand the structural divergence of the cardiac chambers, we determined the contributions of individual embryonic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (9): 1435–1441.
Published: 1 May 2016
... advances presented at the recent Company of Biologists workshop on Transdifferentiation and Tissue Plasticity in Cardiovascular Rejuvenation. Cardiomyocyte Heart Regenerative medicine Stem cells The first organ to be fashioned during embryogenesis – the heart – is the organ...
Journal Articles
Journal: Development
Development (2016) 143 (5): 729–740.
Published: 1 March 2016
... basis of this ineffective cardiac regeneration in mammals is the low proliferative capacity of adult cardiomyocytes. However, mammalian cardiomyocytes can avidly proliferate during fetal and neonatal development, and both adult zebrafish and neonatal mice can regenerate cardiac muscle after injury...
Journal Articles
Journal: Development
Development (2015) 142 (11): 2037–2047.
Published: 1 June 2015
... numerous growth factor signals have been shown to be required for the proliferation of cardiomyocytes, genetic studies have only identified a very limited number of transcription factors that act to regulate the entry of cardiomyocytes into S phase. Here, we report that the cardiac para-zinc-finger protein...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (23): 4418–4431.
Published: 1 December 2014
... compartments. Cardiomyocytes are the main cell type found in the heart and ensure contraction of the chambers and efficient blood flow throughout the body. Injury to the cardiac muscle often leads to heart failure due to the loss of a large number of cardiomyocytes and its limited intrinsic capacity...
Journal Articles
Journal: Development
Development (2014) 141 (22): 4267–4278.
Published: 15 November 2014
... into induced cardiac-like myocytes (iCLMs) in vitro and in vivo . Given that optimal cardiac function relies on distinct yet functionally interconnected atrial, ventricular and pacemaker (PM) cardiomyocytes (CMs), it remains to be seen which subtypes are generated by direct reprogramming and whether...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (15): 3040–3049.
Published: 1 August 2014
... development. Further examination showed that the alteration in cardiac morphology in CHD5-depleted hearts was associated with a decrease in cardiomyocyte cell number (mean=1817±130 versus 1499±184, n ≥3) and a lower mitotic index than stage-matched controls (mean=2.98±0.68 versus 1.07±0.42, n ≥3...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (8): 1639–1644.
Published: 15 April 2013
... expressed in embryonic stem cells (ESCs), GATA4 was shown to promote endoderm, not cardiac mesoderm. The capacity of related GATA factors to promote cardiogenesis is untested. We found that expression of the highly related gene, Gata5 , very efficiently promotes cardiomyocyte fate from murine ESCs. Gata5...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (3): 660–666.
Published: 1 February 2013
...Wen-Yee Choi; Matthew Gemberling; Jinhu Wang; Jennifer E. Holdway; Meng-Chieh Shen; Rolf O. Karlstrom; Kenneth D. Poss Adult mammalian cardiomyocytes have little capacity to proliferate in response to injury, a deficiency that underlies the poor regenerative ability of human hearts after myocardial...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (5): 948–957.
Published: 1 March 2012
... or arrest of the cardiac cell cycle in M-phase and a failure of cardiomyocyte progenitors to incorporate into the developing heart. We show that these defects are a result of an underlying malformation in the formation and polarity of cardiac actin fibers and F-actin deposition. We show that these defects...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (16): 3421–3430.
Published: 15 August 2011
... such as zebrafish are based on invasive surgeries causing mechanical injuries that are limited in size. Here, we created a genetic cell ablation model in zebrafish that facilitates inducible destruction of a high percentage of cardiomyocytes. Cell-specific depletion of over 60% of the ventricular myocardium...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (15): 3331–3340.
Published: 1 August 2011
... ( dornitz@wustl.edu ) Competing interests statement The authors declare no competing financial interests. 23 5 2011 © 2011. Epicardium Cardiac fibroblast Cardiomyocyte FGF10 FGFR2b EPDCs The epicardium comprises the outer layer of the heart and provides...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (14): 2895–2902.
Published: 15 July 2011
..., genetic fate-mapping of larval or adult tcf21 + cells revealed contributions to perivascular cells, but not cardiomyocytes, during each form of cardiogenesis. Our findings indicate that natural epicardial fates are limited to non-myocardial cell types in zebrafish. * Author for correspondence...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (1): 183–192.
Published: 1 January 2008
... mechanisms of cardiac homeostasis in zebrafish, which display indeterminate growth and possess an unusual capacity to regenerate after acute cardiac injury. Lowering fish density in the aquarium triggered rapid animal growth and robust cardiomyocyte proliferation throughout the adult ventricle, greater than...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (22): 4595–4606.
Published: 15 November 2006
... for the continued differentiation of adjacent myocardium. Culture studies using embryonic stem (ES) cell-derived cardiomyocytes revealed that,in a Hand1 -null background, there is significantly elevated cardiomyocyte differentiation, with an apparent default mesoderm pathway to a cardiomyocyte fate. However, Hand1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (7): 1399–1410.
Published: 1 April 2006
...) body plan. To determine how LR positional information becomes `translated' into anatomical asymmetry, left versus right side cardiomyocyte cell lineages were traced in normal and laterality defective embryos of the frog, Xenopus laevis . In normal embryos, myocytes in some regions of the heart were...